骨肿瘤对骨科医生仍然是一个严峻的挑战。在发展中国家，这个挑战在诊断、治疗和管理设施受限以及医疗知识不足的情况下变得更加严重。上肢和下肢肌肉和骨骼肿瘤的患者有可能需要截肢或手术拯救肢体。传统上，新辅助化疗下的肢体拯救手术是治疗局部癌症的首选方法。截肢通常保留给肿瘤体积增大的患者。本研究旨在调查通过手术治疗的恶性骨肿瘤的青少年和年轻成年幸存者的健康相关生活质量（HRQOL）和身体残疾情况，重点关注手术护理、性别和年龄。这项横断面研究包括在2019年至2022年期间在乔治国王医科大学进行截肢或肢体拯救手术的38名长期幸存者。获得伦理许可和知情同意后，纳入了38名患者，其中包括26名接受肢体拯救治疗的A组患者和12名接受截肢治疗的B组患者。使用SF-36和HUI3评分来评估这些患者的功能结果和与健康相关的生活质量。在至少六个月的干预后，我们发现在以下所有因素中都有显著改善：身体功能（P=0.000）、因身体健康问题而造成的角色限制（P=0.000）和情绪问题（P=0.001）、精力/疲劳（P=0.000）、情绪幸福感（P=0.000）、社交功能（P=0.000）、疼痛（P=0.000）和总体健康状况（P=0.000）。通过SF-36（短表格36项，患者报告的结果），A组的显著性程度高于B组；而HUI-3没有显示出任何显著结果（P=0.347）。拯救肢体患者的整体生活质量似乎高于肿瘤幸存者中截肢患者的生活质量。进一步分析必须进行以验证结果，并使用其他评估工具聚焦对整体生活质量有重大影响的方面。治疗对生活质量的影响取决于维持功能的必要结构、调整患者对癌症治疗的期望和设计长期康复计划以支持功能。版权所有©2023年，Kumar等人。

 Bone tumors remain a formidable challenge for orthopedic surgeons. In developing countries, the challenge is exacerbated by limited diagnostic, therapeutic, and management facilities and ignorance. Patients with upper and lower-extremity muscle and skeletal tumors are candidates for amputation or surgical rescue of the limbs. Traditionally, limb rescue surgery by neo-adjuvant chemotherapy is the preferred surgery method for localized carcinoma. Amputations are usually reserved for patients with increased tumor size. The purpose of this study is to investigate health-related quality of life (HRQOL) and physical disability, focusing on surgical care, gender, and age, in adolescent and young adult survivors of malignant bone tumors treated surgically. This cross-sectional study consists of 38 long-term survivors who underwent amputation or limb-salvage surgery at King George's Medical University, Lucknow, from 2019 to 2022. After obtaining ethical clearance and informed consent, 38 patients which included 26 patients treated with limb salvage in Group A and 12 patients treated with amputation in Group B were included in the study. The SF-36 and HUI3 scores were used to assess the functional outcome and health-related QoL of these patients. After minimal six months of interventions, we have found a significant improvement in all the following factors: physical functioning (P=0.000), role limitations due to physical health (P=0.000) and emotional problems (P=0.001), energy/fatigue (P=0.000), emotional well-being (P=0.000), social functioning (P=0.000), pain (P=0.000), and general health (P=0.000). Group A showed a higher degree of significance than Group B through SF-36 (Short Form-36, patient-reported outcome), whereas HUI-3 did not show any significant outcomes (P=0.347). The overall quality of life of patients with salvaged limbs appears to be higher than that of the quality of life of amputee patients in tumor survivor patients. Further analyses must be carried out to verify the results and focus on areas that have a major impact on the overall quality of life using other assessment tools. The impact of therapy on the quality of life depends on maintaining the necessary structures for functional functions, adjusting patient expectations to cancer treatments, and designing long-term rehabilitation programs to support functional functions.Copyright © 2023, Kumar et al.