Pluronic F127水凝胶生物材料因其温度敏感性、可注射性、可生物降解性和保持湿润伤口环境的卓越特性而在伤口愈合和修复方面受到了广泛关注。本综述从F127-CHO、F127-NH2和F127-DA等方面对Pluronic F127衍生水凝胶的最新进展进行了深入探讨，重点关注其在治疗各种类型的伤口上的应用，涵盖烧伤和急性伤口、感染伤口、糖尿病性伤口、皮肤肿瘤伤口和子宫瘢痕等。此外，本综述还详细研究了这些水凝胶在伤口微环境中所采用的复杂相互作用机制。通过阐明其潜在机制，讨论Pluronic F127的优点和缺点，分析伤口愈合发展的现状，并扩展以F127为纳米材料在靶向线粒体和细胞方面的趋势。本综述加深了我们对这些水凝胶的治疗效应的理解，旨在促进有效和安全的伤口愈合方法的发展。本综述提供的有价值见解有潜力激发临床治疗的新思路，并推动创新伤口管理方法的进步。© 2023 Li等人。

Pluronic F127 hydrogel biomaterial has garnered considerable attention in wound healing and repair due to its remarkable properties including temperature sensitivity, injectability, biodegradability, and maintain a moist wound environment. This comprehensive review provides an in-depth exploration of the recent advancements in Pluronic F127-derived hydrogels, such as F127-CHO, F127-NH2, and F127-DA, focusing on their applications in the treatment of various types of wounds, ranging from burns and acute wounds to infected wounds, diabetic wounds, cutaneous tumor wounds, and uterine scars. Furthermore, the review meticulously examines the intricate interaction mechanisms employed by these hydrogels within the wound microenvironment. By elucidating the underlying mechanisms, discussing the strengths and weaknesses of Pluronic F127, analyzing the current state of wound healing development, and expanding on the trend of targeting mitochondria and cells with F127 as a nanomaterial. The review enhances our understanding of the therapeutic effects of these hydrogels aims to foster the development of effective and safe wound-healing modalities. The valuable insights provided this review have the potential to inspire novel ideas for clinical treatment and facilitate the advancement of innovative wound management approaches.© 2023 Li et al.