引言：过去十年来，超增强子（Super-enhancer，SE）作为一个研究热点，受到人们在癌症发生、发展和预后方面的关注。为了揭示癌症研究中SE的热点和其演化趋势，对该主题进行了文献计量分析。方法：系统分类了2022年12月31日前发表在WOSCC上的文献，并使用Citespace、bibliometric.com/app和GraphPad Prism进行了数据分析。结果：在筛选掉不恰当的文献和重复数据后，选取了911篇文献进行进一步的文献计量分析。前五个研究领域分别为肿瘤学（257，28.211%）、细胞生物学（210，23.052%）、生物化学与分子生物学（209，22.942%）、科学技术与其他主题（138，15.148%）和遗传学与遗传（132，14.490%）。美利坚合众国（United States）是文献数量最多的国家（462，50.71%），其次是中国（303，33.26%）。在最具产出的机构中，美国有四个，新加坡有一个，即新加坡国立大学。哈佛医学院（7.68%）的文章百分比最高。Richard A是发表文章数量最多的作者，共发表了32篇文章。前三名作者来自白头研究所的一个研究团队。超过三分之二的研究得到了美国国立卫生研究院的支持（337，37.654%）和美国健康与人类服务部（337，37.654%）。"超增强子"（525）、"细胞身份"（258）、"表达"（223）、"癌症"（205）和"转录因子"（193）是前五个关键词。讨论：自2013年以来，与SE和癌症有关的文献呈现快速增长的趋势。美国在该领域继续发挥领导作用，因为文献数量、机构、资助机构和作者均来自美国，其次是中国和欧洲国家。多个国家之间存在着密切的合作关系。SE在细胞身份、基因转录、表达和抑制，以及SE和转录因子之间的关系，以及对SE的选择性抑制等方面引起了广泛关注，表明这些是研究的热点问题（本文引自：唐，屈，滕，庄，徐和屈，2023）。

Introduction: In the past decade, super-enhancer (SE) has become a research hotspot with increasing attention on cancer occurrence, development, and prognosis. To illustrate the hotspots of SE in cancer research and its evolutionary tendency, bibliometric analysis was carried out for this topic. Methods: Literature published before Dec 31, 2022, in WOSCC, was systematically classified, and Citespace, bibliometric.com/app, and GraphPad Prism analyzed the data. Results: After screening out inappropriate documents and duplicate data, 911 publications were selected for further bibliometric analysis. The top five research areas were Oncology (257, 28.211%), Cell Biology (210, 23.052%), Biochemistry Molecular Biology (209, 22.942%), Science Technology Other Topics (138, 15.148%), and Genetics Heredity (132, 14.490%). The United States of America (United States) has the highest number of documents (462, 50.71%), followed by China (303, 33.26%). Among the most productive institutions, four of which are from the United States and one from Singapore, the National University of Singapore. Harvard Medical School (7.68%) has the highest percentage of articles. Young, Richard A, with 32 publications, ranks first in the number of articles. The top three authors came from Whitehead Institute for Biomedical Research as a research team. More than two-thirds of the research are supported by the National Institutes of Health of the United States (337, 37.654%) and the United States Department of Health Human Services (337, 37.654%). And "super enhancer" (525), "cell identity" (258), "expression" (223), "cancer" (205), and "transcription factor" (193) account for the top 5 occurrence keywords. Discussion: Since 2013, SE and cancer related publications have shown a rapid growth trend. The United States continues to play a leading role in this field, as the top literature numbers, affiliations, funding agencies, and authors were all from the United States, followed by China and European countries. A high degree of active cooperation is evident among a multitude of countries. The role of SEs in cell identity, gene transcription, expression, and inhibition, as well as the relationship between SEs and TFs, and the selective inhibition of SEs, have received much attention, suggesting that they are hot issues for research.Copyright © 2023 Tang, Qu, Teng, Zhuang, Xu and Qu.