引言：大量的研究表明，蛋白质质膜组是细胞过程中的关键调控因子。最近，越来越多的证据表明，蛋白质质膜组在肿瘤进展中起着至关重要的作用。由于尚未发表相关的计量学研究，因此我们进行了计量学和可视化分析，以描绘与蛋白质质膜组与癌症相关的研究知识框架。方法：从Web of Science Core Collection数据库中获取了2003年至2022年期间发表的相关英文研究。使用VOSviewer、CiteSpace、R-bibliometrix等三个程序和计量学网站（http://bibliometric.com/）构建了基于国家、机构、作者、期刊、引用和关键词分析的网络。结果：共提取和鉴定了2463篇文献。美国发表文献最多且总引用次数最多，托马斯·杰斐逊大学是最有成果的机构。迈克尔·P·利桑蒂是这个研究领域中最有影响力的学者。《Cell Cycle》期刊是本主题上发表最多的期刊。最有本地引用的文献是题为《Caveolin-1 in oncogenic transformation, cancer, and metastasis》的文章。基于关键词和引用文献进行了全面的分析。最初的研究前沿主要涉及“信号转导”、“人类乳腺癌”、“癌基因转化细胞”、“肿瘤抑制基因”和“成纤维细胞”。而近年来，研究重点转向“肿瘤微环境”、“上皮间质转化”、“纳米颗粒”和“干细胞”。结论：综上所述，我们的计量学分析显示，蛋白质质膜组在癌症研究中仍然引起关注。研究热点和前沿已从癌症信号调控转向癌症治疗潜在靶点和新技术。这些结果可为未来研究的指导提供基于数据的参考。版权所有 © 2023 Tan and Song.

Introduction: Extensive studies indicated that caveolin is a key regulator in multiple cellular processes. Recently, growing evidence demonstrated that caveolin is critically involved in tumor progression. Since no relevant bibliometric study has been published, we performed a bibliometric and visual analysis to depict the knowledge framework of research related to the involvement of caveolin in cancer. Methods: Relevant studies published in English during 2003-2022 were obtained from the Web of Science Core Collection database. Three programs (VOSviewer, CiteSpace, and R-bibliometrix) and the website of bibliometrics (http://bibliometric.com/) were applied to construct networks based on the analysis of countries, institutions, authors, journals, references, and keywords. Results: A total of 2,463 documents were extracted and identified. The United States had the greatest number of publications and total citations, and Thomas Jefferson University was the most productive institution. Michael P. Lisanti was the most influential scholar in this research domain. Cell Cycle was the journal with the most publications on this subject. The most local-cited document was the article titled "Caveolin-1 in oncogenic transformation, cancer, and metastasis." A comprehensive analysis has been conducted based on keywords and cited references. Initially, the research frontiers were predominantly "signal transduction", "human breast cancer," "oncogenically transformed cells," "tumor suppressor gene," and "fibroblasts." While in recent years, the research emphasis has shifted to "tumor microenvironment," "epithelial mesenchymal transition," "nanoparticles," and "stem cells." Conclusion: Taken together, our bibliometric analysis shows that caveolin continues to be of interest in cancer research. The hotspots and research frontiers have evolved from the regulation of cancer signaling, to potential targets of cancer therapy and novel techniques. These results can provide a data-based reference for the guidance of future research.Copyright © 2023 Tan and Song.