肿瘤相关基因Yes相关蛋白及其具有PDZ结合基序的转录共激活因子(YAP/TAZ) 是位于Hippo、Wnt、GPCR、雌激素、机械和代谢信号调节网络的中心的两个同源转录共激活因子。YAP/TAZ影响代谢循环中下游基因和蛋白的表达以及酶活性、细胞增殖、炎症因子表达和成纤维细胞向肌成纤维细胞的转分化。YAP/TAZ还可以通过表观遗传调控和翻译后修饰调节。因此，这些机制的调节功能使得YAP/TAZ参与代谢相关疾病、动脉粥样硬化、纤维化以及癌症进展和器官再生之间微妙平衡的发病机制。因此，有必要在临床环境中对YAP/TAZ进行深入研究。本文旨在阐明调节YAP/TAZ的信号通路，并探索YAP/TAZ诱导疾病及其潜在治疗干预的机制。此外，我们还总结了目前研究YAP/TAZ靶向治疗的临床研究，同时讨论了现有研究的局限性并提出未来研究的方向。总之，本综述旨在为解析YAP/TAZ介导的信号通路、确定潜在治疗靶点并提供创新解决方案以克服与YAP/TAZ相关的挑战提供新的见解。© 2023作者。由四川国际医药交流促进会(SCIMEA)和John Wiley & Sons Australia, Ltd.出版的MedComm发布。

The Yes-associated protein and its transcriptional coactivator with PDZ-binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism signaling. YAP/TAZ influences the expressions of downstream genes and proteins as well as enzyme activity in metabolic cycles, cell proliferation, inflammatory factor expression, and the transdifferentiation of fibroblasts into myofibroblasts. YAP/TAZ can also be regulated through epigenetic regulation and posttranslational modifications. Consequently, the regulatory function of these mechanisms implicates YAP/TAZ in the pathogenesis of metabolism-related diseases, atherosclerosis, fibrosis, and the delicate equilibrium between cancer progression and organ regeneration. As such, there arises a pressing need for thorough investigation of YAP/TAZ in clinical settings. In this paper, we aim to elucidate the signaling pathways that regulate YAP/TAZ and explore the mechanisms of YAP/TAZ-induce diseases and their potential therapeutic interventions. Furthermore, we summarize the current clinical studies investigating treatments targeting YAP/TAZ. We also address the limitations of existing research on YAP/TAZ and propose future directions for research. In conclusion, this review aims to provide fresh insights into the signaling mediated by YAP/TAZ and identify potential therapeutic targets to present innovative solutions to overcome the challenges associated with YAP/TAZ.© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.