多项研究已对小细胞肺癌患者的各种外周血生物标志物的预测意义进行了调查。然而，这些标志物的预测价值尚未得到验证。本研究评估和评估了常见的营养或炎症指标在接受一线化疗的小细胞肺癌患者中预测总生存期（OS）的能力。2008年1月至2019年7月，在四川大学华西医院招募了560名小细胞肺癌患者。评估了化疗前获得的11项营养或炎症指标。通过最大选择秩统计法确认了连续外周血指标的截断值。通过单变量和多变量Cox回归分析，研究了外周血指标与OS的关系。使用Harrell's一致性指数（C指数）和时间相关的接收器操作特性曲线来评估这些指标的性能。在研究中共招募了560名小细胞肺癌患者，所有患者均接受了一线化疗。在单变量Cox分析中，除了那不勒斯评分外，所有指标与OS相关。在多变量分析中，白蛋白球蛋白比是与预后相关的独立因素。所有指标在OS预测中表现不佳，曲线下面积范围从0.500到0.700不等。乳酸脱氢酶（LDH）和预后营养指数（PNI）是相对较好的预测因子，C指数分别为0.568和0.550。LDH显示出逐渐增加的预测价值，而PNI在生存时间延长时显示出减值，尤其对于男性或吸烟者。具有最高敏感性（0.646）的LDH和具有最高特异性（0.952）的高级肺癌炎症指数（ALI）有助于在不同时间点识别死亡和生存。常见的炎症或营养指标在预测接受一线化疗的小细胞肺癌患者的预后方面仅有较小的用途。其中，LDH、PNI和ALI是相对有希望的预后评估生物标志物。版权所有©2023 Tian, Li, Hou, Jin, Wang, Ren, Wang, Wang, Li和Liu。

Various studies have investigated the predictive significance of numerous peripheral blood biomarkers in patients with small cell lung cancer (SCLC). However, their predictive values have not been validated. This study assessed and evaluated the ability of common nutritional or inflammatory indicators to predict overall survival (OS) in patients with SCLC who received first-line chemotherapy.Between January 2008 and July 2019, 560 patients with SCLC were enrolled at the Sichuan University West China Hospital. Eleven nutritional or inflammatory indices obtained before chemotherapy were evaluated. The cutoff values of continuous peripheral blood indices were confirmed through maximally selected rank statistics. The relationship of peripheral blood indices with OS was investigated through univariate and multivariate Cox regression analyses. Harrell's concordance (C-index) and time-dependent receiver operating characteristic curve were used to evaluate the performance of these indices.A total of 560 patients with SCLC were enrolled in the study. All the patients received first-line chemotherapy. In the univariate Cox analysis, all indices, except the Naples score, were related to OS. In the multivariate analysis, albumin-globulin ratio was an independent factor linked with prognosis. All indices exhibited poor performance in OS prediction, with the area under the curve ranging from 0.500 to 0.700. The lactic dehydrogenase (LDH) and prognostic nutritional index (PNI) were comparatively superior predictors with C-index of 0.568 and 0.550, respectively. The LDH showed incremental predictive values, whereas the PNI showed diminishing values as survival time prolonged, especially for men or smokers. The LDH with highest sensitivity (0.646) and advanced lung cancer inflammation index (ALI) with highest specificity (0.952) were conducive to identifying death and survival at different time points.Common inflammatory or nutritional biomarkers are only marginally useful in predicting outcomes in patients with SCLC receiving first-line chemotherapy. Among them, LDH, PNI, and ALI are relatively promising biomarkers for prognosis evaluation.Copyright © 2023 Tian, Li, Hou, Jin, Wang, Ren, Wang, Wang, Li and Liu.