为了调查沙特育龄妇女对宫颈癌危险因素和人类乳头瘤病毒(HPV)疫苗的了解水平，我们进行了一项匿名、基于调查的横断面研究，时间跨度从2022年11月至2023年3月。总共，我们纳入了422名参与者。大部分参与者年龄在15-25岁之间(42.9%)，未婚(47.9%)，并且有学士学位(70%)。在总分为14分的情况下，所有参与者的平均知识得分为7.3±2.31 (范围: 2-14)。超过四分之三的受访者正确识别了宫颈癌的以下危险因素：多个性伴侣(78.2%)，免疫力减弱(82.7%)，感染HPV(82.9%)和家族中有宫颈癌的历史(88.9%)。关于HPV疫苗，153名(36.3%)参与者听说过HPV疫苗，而只有20名(4.4%)接种过该疫苗。只有128名(30.3%)参与者正确表示9-13岁是开始接种HPV疫苗的最佳年龄，而51名(12.1%)参与者正确表示HPV疫苗接种次数为六个月内的三次。总体而言，167名(39.6%)参与者拒绝接种HPV疫苗。最常报告的三个原因包括没有听说过HPV疫苗(35.3%)，害怕HPV相关的副作用(30.5%)和对HPV疫苗注射有顾虑(16.2%)。在多个社会人口统计特征中，职业与知识得分显著相关(p < 0.001)，与从事卫生专业的学生相比，其他人群的知识得分较低。大部分参与者对宫颈癌危险因素有很好的了解，但对HPV疫苗的了解不足。非常令人担忧的是，不到5%的参与者接种了HPV疫苗，近40%的人拒绝了接种。建议采取机制来增加公众对HPV疫苗的认知，并促使妇女接受该疫苗。© 2023 The Author(s).

To examine the knowledge of cervical cancer risk factors and human papilloma virus (HPV) vaccine among Saudi women of childbearing age.An anonymous, survey-based, cross-sectional study was conducted from November 2022 to March 2023.Overall, 422 participants were included in the current study. Most participants were within the age group of 15-25 years old (42.9%), single (47.9%), and educated with a bachelor's degree (70%). Out of a total of 14 points, the average knowledge score for all participants was 7.3 ± 2.31 (range: 2-14). More than three-quarters of the surveyed participants correctly identified the following risk factors for cervical cancer: multiple sexual partners (78.2%), having weakened immunity (82.7%), infection with HPV (82.9%), and positive family history of cervical cancer (88.9%). Concerning HPV vaccine, 153 (36.3%) participants heard about HPV vaccine and only 20 (4.4%) of them were vaccinated. Only 128 (30.3%) participants stated correctly that 9-13 years old is the best age to start HPV vaccine, whereas 51 (12.1%) participants correctly stated the number of HPV vaccine doses to be three over six months. Overall, 167 (39.6%) participants declined to receive the HPV vaccine. The three most frequently reported reasons included not hearing about HPV vaccine (35.3%), fear from HPV-related side effects (30.5%), and apprehension from HPV vaccine injection (16.2%). Among several socio-demographic characteristics, occupation was statistically significantly associated with knowledge score (p < 0.001), with students in health specialties tended to have the highest knowledge score compared with others.Most participants displayed good knowledge about cervical cancer risk factors, but not about HPV vaccine. Very alarmingly, less than 5% of the participants received HPV vaccine and close to 40% of them declined to receive the HPV vaccine. Mechanisms to increase public awareness about HPV vaccine and its acceptance by women are recommended.© 2023 The Author(s).