肝细胞癌（Hepatocellular Carcinoma，HCC）合并微血管侵袭时，生物标志物在其中扮演的角色及其分子机制：一项综述。
Roles and Molecular Mechanisms of Biomarkers in Hepatocellular Carcinoma with Microvascular Invasion: A Review.
发表日期：2023 Oct 28
作者：
Xudong Zhao, Yudan Wang, Haoming Xia, Shuqiang Liu, Ziyue Huang, Risheng He, Liang Yu, Nanfeng Meng, Hang Wang, Junqi You, Jinglin Li, Judy Wai Ping Yam, Yi Xu, Yunfu Cui
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要：
肝细胞癌（HCC）作为导致癌症相关死亡的主要原因，其相关死亡率和复发率较高。寻找有效的HCC诊断和治疗措施已经成为迫切需要。研究表明，微血管侵袭（MVI）是肝切除术后预后不良的独立危险因素。HCC患者中如circ-RNAs，lncRNAs，STIP1和PD-L1等生物大分子的异常表达与MVI存在强相关性。本文综述了本文提到的几种标志物的失调通过多种复杂机制影响HCC细胞的增殖、侵袭、转移、EMT和抗凋亡过程。因此，这些生物标志物可能在临床中起重要作用，并可作为HCC有前途的干预靶点。在本综述中，我们全面概述了HCC中与MVI相关的生物标志物的功能和调控机制。 © 2023 Authors.
Hepatocellular carcinoma (HCC) being a leading cause of cancer-related death, has high associated mortality and recurrence rates. It has been of great necessity and urgency to find effective HCC diagnosis and treatment measures. Studies have shown that microvascular invasion (MVI) is an independent risk factor for poor prognosis after hepatectomy. The abnormal expression of biomacromolecules such as circ-RNAs, lncRNAs, STIP1, and PD-L1 in HCC patients is strongly correlated with MVI. Deregulation of several markers mentioned in this review affects the proliferation, invasion, metastasis, EMT, and anti-apoptotic processes of HCC cells through multiple complex mechanisms. Therefore, these biomarkers may have an important clinical role and serve as promising interventional targets for HCC. In this review, we provide a comprehensive overview on the functions and regulatory mechanisms of MVI-related biomarkers in HCC.© 2023 Authors.