胞外分泌的富含半胱氨酸的酸性蛋白（SPARC），也被称为骨基质结合素或BM-40，是一种基质细胞蛋白，用来调节细胞粘附、细胞外基质产生、生长因子活性和细胞周期。尽管SPARC不具备结构功能，但由于其抗增殖和抗粘附特性，它可以调控细胞与周围细胞外基质之间的相互作用。SPARC在损伤、再生、肥胖、癌症和炎症等部位的过表达显示了其作为治疗和疾病评估的潜在靶点和治疗指标的应用。本文全面总结了SPARC在炎症和肿瘤中的过表达机制以及功能纳米材料在以SPARC为新靶点治疗类风湿性关节炎和肿瘤方面的最新研究进展。本文提供了利用功能纳米材料通过SPARC靶向治疗炎症性疾病的思路。本文旨在为基于SPARC靶向治疗的疾病研究提供参考。版权所有© 2023 江、孙、李、张、陈和刘。

Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a matricellular protein which regulates cell adhesion, extracellular matrix production, growth factor activity, and cell cycle. Although SPARC does not perform a structural function, it, however, modulates interactions between cells and the surrounding extracellular matrix due to its anti-proliferative and anti-adhesion properties. The overexpression of SPARC at sites, including injury, regeneration, obesity, cancer, and inflammation, reveals its application as a prospective target and therapeutic indicator in the treatment and assessment of disease. This article comprehensively summarizes the mechanism of SPARC overexpression in inflammation and tumors as well as the latest research progress of functional nanomaterials in the therapy of rheumatoid arthritis and tumors by manipulating SPARC as a new target. This article provides ideas for using functional nanomaterials to treat inflammatory diseases through the SPARC target. The purpose of this article is to provide a reference for ongoing disease research based on SPARC-targeted therapy.Copyright © 2023 Jiang, Sun, Li, Zhang, Chen and Liu.