热休克蛋白90（Hsp90）是参与许多不同生物过程，尤其是细胞存活的蛋白质。其中一些功能需要其他生物分子的参与，因此Hsp90是参与许多蛋白质-蛋白质相互作用的伴侣蛋白，起着关键的信号传导枢纽作用。作为热休克蛋白家族的成员，Hsp90的表达受特定环境和/或有压力的情况调节，因此可以监测Hsp90浓度并与这些效应相关联。本综述讨论了来自不同疾病（从感染性疾病到癌症）患者样本中的Hsp90表达以及这些疾病的生物学结果，包括Hsp90作为人类疾病诊断生物标志物的潜在用途。关于感染性疾病和癌症方面，Hsp90作为疾病生物标志物的潜力已经在多个研究中得到证明。然而，这一领域仍需要进一步的研究，主要是在统计学显著的临床研究中验证Hsp90蛋白的检测是否能够早期诊断某些癌症，并且它是否能作为监测癌症治疗效果的生物标志物。

The heat shock protein 90 (Hsp90) is a protein involved in many different biological processes and especially in cell survival. Some of these functions require the participation of other biological molecules, so Hsp90 is a chaperone that takes part in many protein-protein interactions working as a critical signaling hub protein. As a member of the heat shock protein family, Hsp90 expression is regulated under certain environmental and/or stressful situations, therefore Hsp90 concentration can be monitored and linked to these effects.This review discusses the Hsp90 expression in samples from individuals affected by different diseases (from infectious to cancer origin), and the biological consequences of these disorders, including the potential use of Hsp90 as a biomarker for diagnosis of human diseases.The potential of Hsp90 as a biomarker disease has been demonstrated in several studies in relation to infectious diseases and especially cancer. However, further research in this field is still needed, mainly to validate in statistically significant clinical studies that the detection of Hsp90 protein allows the diagnosis of some cancers at an early stage and also that it can act as a biomarker for monitoring the efficacy of their therapies.