蛛网膜胶质瘤病（LG）以肿瘤性胶质细胞在蛛网膜下提分散为特征，其可无原发性脑实质胶质瘤（原发性LG或PLG）或与脑实质胶质瘤相伴而来（继发性LG或SLG）。鉴于LG在人类和兽医学中的低发性，目前尚缺失特定的诊断标准。本文回顾性地描述了来自6所学术机构的14例犬LG。患病狗的平均年龄为7.3岁，超过90％的患者为短头型犬。临床症状各异且进行性加重。其中7/14只狗的磁共振图像结果显示受影响区域蛛网膜强化和/或脑内实质肿块。所有患病犬因预后不良而被安乐死。其中12/14例患病犬存在明显病变，主要表现为脑部（6/12例）或脊髓（2/12例）的胶质瘤病理下的明胶样蛛网膜增厚和脑部（6/12例）的一个或多个明胶样的灰色至红色脑内肿块。组织学上，所有的蛛网膜肿瘤和脑内胶质瘤形态学与少突胶质细胞瘤一致。所有肿瘤中普遍阳性的核抗原标记物OLIG2的免疫染色也得以观察。在3例病例中，无原发性脑内胶质瘤与PLG一致。其余11例被诊断为SLG。

Leptomeningeal gliomatosis (LG) is characterized by extensive dissemination of neoplastic glial cells in the subarachnoid space either without an intraparenchymal glioma (primary LG or PLG) or secondary to an intraparenchymal glioma (secondary LG or SLG). Given the low frequency of LG in human and veterinary medicine, specific diagnostic criteria are lacking. Here, we describe 14 cases of canine LG that were retrospectively identified from 6 academic institutions. The mean age of affected dogs was 7.3 years and over 90% of patients were brachycephalic. Clinical signs were variable and progressive. Relevant magnetic resonance image findings in 7/14 dogs included meningeal enhancement of affected areas and/or intraparenchymal masses. All affected dogs were euthanized because of the poor prognosis. Gross changes were reported in 12/14 cases and consisted mainly of gelatinous leptomeningeal thickening in the brain (6/12 cases) or spinal cord (2/12 cases) and 1 or multiple, gelatinous, gray to red intraparenchymal masses in the brain (6/12 cases). Histologically, all leptomeningeal neoplasms and intraparenchymal gliomas were morphologically consistent with oligodendrogliomas. Widespread nuclear immunolabeling for OLIG2 was observed in all neoplasms. The absence of an intraparenchymal glioma was consistent with PLG in 3 cases. The remaining 11 cases were diagnosed as SLG.