背景：肿瘤与血清丝氨酸水平失调有关，肿瘤生长得到了丝氨酸生物合成的支持。本研究旨在探讨血清丝氨酸水平与中国高血压成年人发生癌症风险的关联。材料与方法：在这项嵌套病例对照研究中，纳入了1391名新发癌症患者和与病例年龄、性别和居住地配对的同样数量的对照组患者。基线时采用液相色谱串联四极杆质谱法(LC-MS/MS)测定了血清丝氨酸浓度。通过条件 logistic 回归分析评估了血清丝氨酸水平与总癌症、消化系统癌症、非消化系统癌症和肺癌(最常见类型)的风险之间的关联。结果：当将血清丝氨酸浓度分为四分位数进行评估时，最高四分位组（≥17.68 μg mL-1）的参与者与最低四分位组（<13.27 μg mL-1）相比，在总癌症风险上存在显著增加 (OR = 1.32; 95% CI: 1.01-1.71; P = 0.038)。类似的结果也观察到了非消化系统和肺癌，但在消化系统癌症方面没有观察到显著的结果。在所有年龄亚组、男性、非吸烟者、非饮酒者和叶酸水平较低的个体中，血清丝氨酸与总癌症风险存在显著关联。结论：中国高血压成年患者高血清丝氨酸浓度与总癌症、非消化系统癌症和肺癌的风险增加相关。

Background: Cancer is associated with the dysregulation of serum serine levels, and tumor growth is supported by increased serine biosynthesis. This study aims to explore the association of serum serine levels with incident cancer risk in Chinese hypertensive adults. Materials and methods: 1391 patients with incident cancer and 1391 matched controls in terms of age, sex, and residence with cases in a 1 : 1 ratio were included in this nested case-control study. The serum serine concentrations were determined by liquid chromatography with tandem quadrupole mass spectrometry (LC-MS/MS) at the baseline. The associations of serum serine levels with the risk of overall, digestive system, non-digestive system, and lung cancers (the most common type) were assessed by conditional logistic regression. Results: When serum serine concentration was assessed as quartiles, a significantly higher risk of total cancer (OR = 1.32; 95% CI: 1.01-1.71; P = 0.038) was found in participants in the highest quartile (≥17.68 μg mL-1) compared with participants in the lowest quartile (<13.27 μg mL-1). Similar results were also observed for non-digestive system and lung cancers, but not for digestive system cancers. Significant associations of serum with overall cancer risk were found among all age subgroups, men, non-smokers, non-drinkers, and individuals with lower folic acid levels. Conclusion: High serum serine concentrations were associated with an increased risk of overall, non-digestive system, and lung cancers among Chinese hypertensive adult patients.