为了探索慢性髓系白血病（CML）患者在Omicron大流行期间COVID-19的患病率和严重程度以及其心理健康情况，我们进行了一项横断面调查，共收集了2609名CML患者的回答。其中，1725名患者（66%）报告在此期间患有COVID-19。其中，1621名患者（94%）为轻型病例，97名患者（6%）为中度病例，7名患者（0.4%）为重度病例，而没有病例属于危重或死亡。403名患者（15%）、199名患者（8%）和532名患者（20%）出现中度至重度的抑郁、焦虑和困扰。890名患者（34%）、667名患者（26%）和573名患者（22%）分别出现回避、侵入和过度激活的症状。多变量分析结果显示，较长的酪激酶抑制剂（TKI）治疗时间与COVID-19患病率显著负相关（比值比[OR] = 0.98；95%置信区间[CI]，0.95，0.99；p = 0.043）。然而，居住在城市地区（OR = 1.6 [1.3, 2.0]; p < 0.001）和有家庭成员患有COVID-19（OR = 18.6 [15.1, 22.8]; p < 0.001）与COVID-19患病率显著正相关。增加的年龄（OR = 1.2 [1.1, 1.4]; p = 0.009）、合并疾病（OR = 1.7 [1.1, 2.7]; p = 0.010）以及接受第三代TKI或研究药物治疗的多重TKI抵抗患者（OR = 2.2 [1.2, 4.2]; p = 0.010）与中度或严重COVID-19相关。女性、合并疾病、未接种疫苗以及中度或严重COVID-19与几乎所有不良心理健康后果显著相关；年龄增长或由于大流行期间的各种限制而被迫降低TKI剂量与中度至重度困扰、回避或侵入明显相关；然而，轻型COVID-19以及无或轻度焦虑、困扰、回避或侵入与这些因素无关。总之，较短的TKI治疗时间、增加的年龄、合并疾病或接受第三代TKI或研究药物治疗的多重TKI抵抗患者在CML患者中患COVID-19的患病率较高，或有中度或严重疾病的风险增加；年龄增长、女性、合并疾病、由于大流行导致的被迫降低TKI剂量、中度或严重COVID-19以及未接种疫苗与心理健康不良的可能性较高。© 2023. 作者（S）独家授权于Springer-Verlag GmbH Germany，属于Springer Nature的一部分。

To explore the prevalence and severity of COVID-19 and the mental health during the Omicron pandemic in patients with chronic myeloid leukemia (CML), a cross-sectional survey from 2609 respondents with CML was performed. A total of 1725 (66%) reported that they had COVID-19 during this period. Among them, 1621 (94%) were mild; 97 (6%), moderate; 7 (0.4%), severe; and 0, critical or death. Four hundred three (15%), 199 (8%), and 532 (20%) had moderate to severe depression, anxiety, and distress, respectively. Eight hundred ninety (34%), 667 (26%), and 573 (22%), avoidance, intrusion, and hyper-arousal, respectively. In multivariate analyses, longer TKI-therapy duration was significantly associated with a lower prevalence of COVID-19 (odds ratio [OR] = 0.98; 95% confidence interval [CI], 0.95, 0.99; p = 0.043); however, living in urban areas (OR = 1.6 [1.3, 2.0]; p < 0.001) and having family members with COVID-19 (OR = 18.6 [15.1, 22.8]; p < 0.001), a higher prevalence of COVID-19. Increasing age (OR = 1.2 [1.1, 1.4]; p = 0.009), comorbidity(ies) (OR = 1.7 [1.1, 2.7]; p = 0.010), and multi-TKI-resistant patients receiving 3rd-generation TKIs or investigational agents (OR = 2.2 [1.2, 4.2]; p = 0.010) were significantly associated with moderate or severe COVID-19. Female, comorbidity(ies), unvaccinated, and moderate or severe COVID-19 were significantly associated with almost all adverse mental health consequences; increasing age or forced TKI dose reduction because of various restriction during the pandemic, moderate to severe distress, avoidance, or intrusion; however, mild COVID-19, none or mild anxiety, distress, avoidance, or intrusion. In conclusion, shorter TKI-therapy duration, increasing age, comorbidity(ies), or multi-TKI-resistant patients receiving 3rd-generation TKIs or investigational agents had a higher prevalence of COVID-19 or higher risk of moderate or severe disease in patients with CML; increasing age, female, comorbidity(ies), forced TKI dose reduction due to the pandemic, moderate or severe COVID-19, unvaccinated, a higher likelihood of worse mental health.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.