小细胞肺癌（SCLC）是一种非常侵袭性的神经内分泌肿瘤，预后不良。虽然免疫治疗已成为治疗SCLC的一种有前景的方法，但其独特的肿瘤免疫微环境（TIME）可能限制患者的反应。充分表征TIME并理解其形成机制对于SCLC至关重要。近年来多组学技术的快速发展迅速增进了对TIME特征以及与SCLC相关的调控机制的认识。本综述总结了SCLC的TIME特征以及通过肿瘤的基因组学、表观基因组学和代谢组学塑造TIME的机制。还讨论了免疫治疗的未来机遇和挑战。版权所有 © 2023 作者。由Elsevier Ltd.出版。保留所有权利。

Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine tumor with a poor prognosis. Whereas immunotherapy has emerged as a promising approach for treating SCLC, its unique tumor immune microenvironment (TIME) might limit patient responses. To fully characterize the TIME and understand the mechanism of its formation with respect to SCLC is crucial. The recent rapid development of multi-omics technologies has rapidly advanced knowledge of TIME features and the regulatory mechanisms associated with SCLC. This review summarizes the TIME features of SCLC as well as shaping the TIME according to the genomics, epigenomics, and metabolomics of tumors. Future opportunities and challenges for immunotherapy are also discussed.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.