前臂软组织肉瘤切除的结果。
Results of resection of forearm soft tissue sarcoma.
发表日期:2023 Aug 14
作者:
Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Ryuichi Nakahara, Haruyoshi Katayama, Takuto Itano, Toshifumi Ozaki
来源:
Bone & Joint Journal
摘要:
前臂软组织肉瘤(Soft Tissue Sarcomas, STS)罕见。我们的目标是评估其肿瘤学和功能性结果。我们回顾性评估了1993年至2020年期间,在我们机构接受前臂STS手术切除的34名患者。我们分析了术后肌骨肿瘤学会评分(Musculoskeletal Tumor Society rating scale, MSTS)、无局部复发生存率(local recurrence-free survival, LRFS)、无转移生存率和总生存率(Overall Survival, OS)。以下变量的意义被确定:年龄、性别、组织学、肿瘤大小、Fédération Nationale des Centres de Lutte contre le Cancer分级、美国联合委员会癌症分期、手术切缘、非计划摘除,初次发现的转移病灶、化疗和放疗(RT)。
术后的MSTS中位数评分为28。骨切除或重要神经麻痹是唯一影响MSTS评分的因素。有骨切除或重要神经麻痹的患者的MSTS中位数评分分别为24和29(P < 0.001)。5年无局部复发生存率为87%。单因素分析显示粘液纤维肉瘤的组织学诊断是影响LRFS的唯一因素(P = 0.047)。5年无转移生存率为71%。在单因素分析中,没有与MFS相关的因素。5年总生存率为79%。年龄是影响OS的唯一因素(P = 0.01)。
在前臂STS的治疗中,皮肤和肌腱的重建可以补偿功能,而骨切除和重要神经问题则不能。细致的随访非常重要,尤其是对于粘液纤维肉瘤的患者,因为其局部复发的可能性较大。© 2023. BioMed Central有限公司,Springer Nature的一部分。
Soft tissue sarcomas (STS) of the forearm are rare. We aim to assess their oncological and functional outcomes.We retrospectively evaluated 34 patients who underwent surgical excision for forearm STS at our institution between 1993 and 2020. We analyzed postoperative Musculoskeletal Tumor Society rating scale (MSTS) and local recurrence-free survival (LRFS), metastasis-free survival, and overall survival (OS) rates. The significance of the following variables was determined: age, sex, histology, tumor size, Fédération Nationale des Centres de Lutte contre le Cancer grade, American Joint Committee on Cancer stage, surgical margin, unplanned excision, metastases upon initial presentation, receipt of chemotherapy, and radiotherapy (RT).The postoperative median MSTS score was 28. Bone resection or major nerve palsy was the only factor that influenced MSTS scores. The median MSTS scores in patients with or without bone resection or major nerve palsy were 24 and 29, respectively (P < 0.001). The 5-year LRFS rates was 87%. Univariate analysis revealed that the histological diagnosis of myxofibrosarcoma was the only factor that influenced LRFS (P = 0.047). The 5-year MFS rates was 71%. In univariate analysis, no factors were associated with MFS. The 5-year OS rates was 79%. Age was the only factor that influenced OS (P = 0.01).In the treatment of forearm STS, reconstruction of the skin and tendon can compensate for function, while bone resection and major nerve disturbance cannot. Careful follow-up is important, especially in patients with myxofibrosarcoma, due to its likelihood of local recurrence.© 2023. BioMed Central Ltd., part of Springer Nature.