治疗相关性急性髓性白血病（tAML）是非霍奇金淋巴瘤（NHL）患者在接受化疗或放疗后的严重并发症。本次广泛的数据库研究旨在量化NHL患者tAML的风险，并确定tAML对NHL患者总体生存率（OS）的影响。通过对Surveillance, Epidemiology, and End Results数据库中2009年至2018年确诊为NHL和先天性AML的患者进行辨别。使用SEER*Stat软件的多个独立初生标准化率（SIR）计算会话来计算SIR和tAML的绝对过量风险。使用Kaplan-Meier曲线评估总生存率（OS），并使用log-rank检验进行比较。使用多变量分析来研究每个协变量对tAML患者的OS的作用。 tAML的SIR为4.89（95% CI 4.41-5.41），年龄<60岁，2013年之前和诊断时间在5年内的NHL患者以及接受化疗的患者tAML的发生率更高。与没有tAML的NHL患者相比，具有tAML的患者的总生存率较低（5年生存率59% vs. 13%，p < 0.001）。tAML患者的总生存率在单变量分析中明显较先天性AML差（5年生存率13% vs. 25%，p = 0.001），但在多变量分析中没有差异（HR 0.93，95% CI 0.82-1.04，p = 0.21）。年龄≥60岁和未接受化疗与tAML亚类中的较差总生存率相关。 年龄、自NHL诊断开始的时间以及化疗接受情况直接影响NHL幸存者患上tAML的风险。

Therapy-related acute myeloid leukemia (tAML) is a serious complication in patients with Non-Hodgkin lymphoma (NHL) exposed to chemotherapy or radiation. This extensive database study aims to quantify the risk of tAML in NHL and determine the impact of tAML on the overall survival (OS) of patients with NHL.Patients diagnosed with NHL and de novo AML from 2009 to 2018 were identified from the Surveillance, Epidemiology, and End Results database. Multiple primary standardized incidence ratio (SIR) sessions of the SEER*Stat software were used to calculate SIR and the absolute excess risk of tAML. Overall survival (OS) was evaluated using Kaplan-Meier curves and compared using log-rank tests. Multivariate analysis was used to study the role of each covariate on OS in patients with tAML.The SIR of tAML was 4.89 (95% CI 4.41-5.41), with a higher incidence of tAML observed for age <60 years, NHL prior to 2013 and within 5 years of diagnosis, and those who received chemotherapy. NHL patients with tAML had lower OS than those without tAML (5-year OS 59% vs. 13%, p < 0.001). Patients with tAML showed worse OS than de novo AML in univariate analysis (5-year OS 13% vs. 25%, p = 0.001) but not in multivariate analysis (HR 0.93, 95% CI 0.82-1.04, p = 0.21). Age ≥60 years and lack of chemotherapy were associated with poor OS in tAML subcategory.Age, time since NHL diagnosis, and receipt of chemotherapy directly influence the risk of development of tAML in NHL survivors.