酒精中毒是一个全球性的健康问题。由于其作为乙醇代谢的主要场所，肝脏承受了来自酗酒的最严重的组织损伤。慢性和大量饮酒会导致多种肝脏病变，包括脂肪肝、肝炎以及纤维化/肝硬化。脂肪肝是由于乙醇氧化反应引起的从被氧化形式到还原形式的烟酰胺腺嘌呤二核苷酸（NAD+）的氧化还原位移。与酒精诱导的肝损伤进展相关的其他分子机制包括增加类固醇调节元件结合蛋白-1（SREBP-1）的活性，降低PPAR-α的活性，细胞信号通路受损，活性氧（ROS）积累以及脂质过氧化。姜黄的根茎富含一种叫做姜黄素的物质，它自然呈黄色，也被称为姜黄黄素。姜黄素具有强大的生物学和药理学特性，包括抗氧化、抗炎、抗真菌、抗菌、抗肿瘤和抗癌作用。它已被用作一种肝脏保护物质。目前的研究表明姜黄素能够通过内毒素抑制NF-κB在库普氏细胞中的活化，抑制各种细胞因子、趋化因子、环氧合酶-2（COX-2）和iNOS的表达，并调节免疫反应。本研究展示了姜黄素在各种肝毒性过程中的重要作用，并总结了这些效应，着重于它们提供的分子洞察力。版权© Bentham Science Publishers；如有任何疑问，请发送邮件至epub@benthamscience.net。

Alcoholism is a global health concern. Due to its role as the principal site of ethanol metabolism, the liver endures the most significant amount of tissue damage from heavy drinking. Numerous liver lesions can result from chronic and heavy alcohol use, including steatosis, hepatitis, and fibrosis/cirrhosis. Fatty liver is caused by a redox shift from the oxidized to the reduced form of nicotinamide adenine dinucleotide (NAD+) caused by the ethanol oxidation reaction. The other molecular mechanisms related to the progression of alcohol-induced liver injury are increasing sterol regulatory element-binding protein-1 (SREBP-1) and decreasing PPAR-α activity, cell signaling pathway impairment, reactive oxygen species (ROS) accumulation, and lipid peroxidation. Curcuma longa L. rhizomes contain a substance called curcumin, which is naturally yellow in color and is also known as turmeric yellow. Curcumin has powerful biological and pharmacological properties, including antioxidant, anti-inflammatory, antifungal, antibacterial, antitumor, and anticancer effects. It's been employed as a hepatoprotective substance. Current studies have demonstrated the ability of curcumin to prevent the activation of NF-κB in Kupffer cells via endotoxins, to suppress the expression of various cytokines, chemokines, cyclooxygenase-2 (COX-2), and iNOS, as well as to modulate immune responses. The present study has shown the vital role of curcumin in a variety of hepatotoxic procedures, and summarizes those effects, focusing on the molecular insights they provide.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.