睾丸癌的管理:局部阶段的实践调查。
Management of testicular cancer: Practice survey in localized stage.
发表日期:2023 Aug
作者:
Benoît Mesnard, Jean-François Hetet, Emmanuel Couteau, Arthur Fosse, Vincent Bocquillon, Alexis Gignoux, Michel Baron, Nicolas Gaschignard, Jérôme Rigaud
来源:
Best Pract Res Cl Ob
摘要:
睾丸癌的管理需要进行完整评估,以确认定位的阶段并根据指南提供有效的治疗,以确保最佳结果。本研究的主要目标是评估局部睾丸肿瘤患者在每个治疗阶段的实践。次要目标是根据治疗方式评估这些患者的肿瘤学预后。我们进行了一项多中心实践评估研究,回顾性收集和评估患者记录。该研究在法国的两个部门(200万居民)于2010年1月1日至2015年1月31日期间进行,为患者提供了为期五年的随访。根据美国癌症联合委员会的分类,纳入了I期睾丸肿瘤患者的分析。总共分析了226份记录;93%的患者进行了双侧阴囊超声和93.25%进行了胸腹盆腔CT扫描。总共29.65%的患者按照指南进行了术前肿瘤标志物分析;94%的患者进行了全睾丸切除术,中位时间为15天。随访期结束时,共有17名患者复发了疾病。按照指南提供辅助治疗可以降低半球细胞瘤患者复发的风险。我们的研究显示,在评估和治疗局部睾丸肿瘤患者时,遵循指南的合规性存在异质性。一些重要的实践措施,如肿瘤标志物的测定和超过40岁患者的生育保护,执行不好。辅助管理局部肿瘤似乎是复发的重要预测因素。
Management of testicular cancer requires a complete evaluation to confirm the localized stage and effective treatment according to guidelines to ensure the best outcome. The primary objective of this study was to evaluate practices at each stage of care in patients with a localized testicular tumor. The secondary objective was to evaluate the oncological prognosis of these patients according to the modalities of care.We conducted a multicenter practice evaluation study with retrospective collection and evaluation of patient records. The study was conducted in two French departments (population pool of 2 million inhabitants) between January 1, 2010, and January 31, 2015, enabling a five-year followup of patients. Patients presenting with stage I testicular tumor according to the American Joint Committee on Cancer classification were included in the analysis.A total of 226 records were analyzed; 93% of patients underwent bilateral scrotal ultrasound and 93.25% had a chest-abdomen-pelvis computed tomography scan. A total of 29.65% of patients had a preoperative tumor marker assay in accordance with guidelines; 94% of patients had a total orchiectomy, with a median time of 15 days. At the end of the followup period, 17 patients had suffered a recurrence of their disease. Providing adjuvant care in accordance with guidelines reduced the risk of recurrence in patients with a seminomatous tumor.Our study showed heterogeneity in compliance with guidelines for evaluation and effective treatment of patients with a localized testicular tumor. Some essential practices, such as assays of tumor markers and fertility preservation for patients over 40 years, were not well carried out. Adjuvant management of localized tumors appears to be an important predictor of recurrence.