根据推介，BRCA突变携带者建议接受对侧预防性乳腺切除术（CPM），非携带者接受与患者选择相关。我们对BRCA携带者和非携带者在预防性乳腺切除术（CPM）后的满意度和福祉进行了特征化描述。在2016年至2022年间，我们在一家单一机构进行了CPM术前和术后的BREAST-Q数据收集，其中包括立即重建手术。我们评估了BRCA状态与对乳房满意度、心理社会福祉和性福福祉之间的关联，并根据术前评分和相关混杂因素进行了调整。 总共包括149名BRCA携带者和842名非携带者。回应率随时间变化（术前，56％；6个月，78％；1年，51％；2年，52％；3年，59％）。BRCA携带者年龄较小（p < 0.001），新辅助化疗率较高（p < 0.001）。更多的非携带者患有HR+/HER2-肿瘤（p < 0.001），并接受内分泌治疗（p < 0.001）。BRCA携带者的基线乳房满意度较高（中位数[四分位范围]评分，70 [53-82] vs. 58 [48-70]；p = 0.006）；心理社会福祉（p = 0.20）和性福福祉（p = 0.14）在两组之间没有显著差异。BRCA携带者在术前到6个月期间乳房满意度（p = 0.04）和心理福祉（p = 0.05）的减少更大；性福福祉的减少（p = 0.38）在两组之间没有显著差异。在单变量和多变量分析中，BRCA状态与对乳房满意度、性福福祉或心理社会福祉无关。 BRCA携带者和非携带者接受CPM治疗后的满意度和福祉相似。与非携带者相比，在CPM术后6个月，BRCA携带者对乳房满意度和心理社会福祉的下降更大。© 2023. Society of Surgical Oncology.

Contralateral prophylactic mastectomy (CPM) is recommended for BRCA mutation carriers; its use in noncarriers relies on patient choice. We characterized differences in satisfaction and well-being after CPM between BRCA carriers and noncarriers.BREAST-Q data were obtained before and after CPM with immediate reconstruction performed at a single institution from 2016 to 2022. Associations between BRCA status and satisfaction with breasts, psychosocial well-being, and sexual well-being were assessed, with adjustment for preoperative scores and relevant confounders.In total, 149 BRCA carriers and 842 noncarriers were included. Response rates varied over time (preoperative, 56%; 6 months, 78%; 1 year, 51%; 2 years, 52%; 3 years, 59%). BRCA carriers were younger (p < 0.001), with a higher rate of neoadjuvant chemotherapy (p < 0.001). More noncarriers had HR+/HER2- tumors (p < 0.001) and underwent endocrine therapy (p < 0.001). Baseline satisfaction with breasts was higher among BRCA carriers (median [interquartile range] score, 70 [53-82] vs. 58 [48-70]; p = 0.006); psychosocial (p = 0.20) and sexual (p = 0.14) well-being were not significantly different between groups. BRCA carriers had a greater decrease in satisfaction with breasts (p = 0.04) and psychological well-being (p = 0.05) from baseline to 6 months; decrease in sexual well-being (p = 0.38) was not significantly different between groups. On univariate and multivariable analyses, BRCA status was not associated with satisfaction with breasts, sexual well-being, or psychosocial well-being.Satisfaction and well-being were similar between BRCA carriers and noncarriers treated with CPM. Relative to noncarriers, BRCA carriers experienced a greater decline in satisfaction with breasts and psychological well-being at 6 months after CPM.© 2023. Society of Surgical Oncology.