转移是导致癌症患者死亡的主要原因。转移抑制基因是一类基因，在转移性肿瘤细胞中重新表达到非转移性细胞中观察到的水平时，显著减少转移，而不影响原发肿瘤的生长。对30个以上的转移抑制基因的分析揭示了包括多个信号通路，转录模式，转录后调控机制和基因组稳定性潜在贡献在内的复杂作用机制。在临床测试中，重新建立已经验证的转移抑制通路的策略最好定向于辅助治疗，旨在抑制隐匿微转移的增长。©2023年。这是一份美国政府作品，不受版权保护；可能适用外国版权保护。

Metastasis is the leading cause of cancer patient mortality. Metastasis suppressors are genes that, upon reexpression in metastatic tumor cells to levels observed in their nonmetastatic counterparts, significantly reduce metastasis without affecting the growth of the primary tumor. Analysis of > 30 metastasis suppressors revealed complex mechanisms of action that include multiple signaling pathways, transcriptional patterns, posttranscriptional regulatory mechanisms, and potential contributions of genomic stability. Clinical testing of strategies to re-establish a validated metastasis suppressor pathway in tumors is best directed to the adjuvant setting, with the goal of inhibiting the outgrowth of occult micrometastases.© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.