艾滋病(HIV)感染患者中超过90%的患者在疾病过程中至少出现一种黏膜皮肤表现。关于马达加斯加HIV感染患者的皮肤发现，目前没有足够的数据。本研究旨在评估马达加斯加HIV感染患者的黏膜皮肤表现谱及其与CD4细胞计数的关系。从2013年1月到2020年3月，在马达加斯加安塔那那利佛大学医院传染病科就诊的HIV阳性患者进行了横断面研究。纳入的对象为年满18岁且接受抗逆转录病毒治疗的HIV阳性患者以及等待接受抗逆转录病毒治疗的患者。在参与本研究的328名患者中，167名(51%)患者出现了至少一种类型的黏膜皮肤损伤。口腔念珠菌病是最常见的表现，其次是脂溢性皮炎和卡波西肉瘤。CD4细胞计数下降与口腔念珠菌病、梅毒和尖锐湿疣有显著相关性。根据我们的发现，口腔念珠菌病、梅毒和尖锐湿疣可作为预测患者免疫状态的临床指标。随着HIV感染的进展和免疫功能下降，皮肤病变的增加。©Fandresena Arilala Sendrasoa, Volatiana Mercia Falimiarintsoa, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja. 原始发表于 JMIR 皮肤病学（http://derma.jmir.org），2023年8月15日。

More than 90% of HIV-infected patients present with at least one mucocutaneous manifestation during the course of their disease. Insufficient data are available regarding dermatologic findings among HIV-infected patients in Madagascar.This study aimed at evaluating the spectrum of mucocutaneous manifestations and their relationship with CD4 cell counts in HIV-infected patients in Madagascar.A cross-sectional study on HIV-positive patients attending the Department of Infectious Diseases in the University Hospital of Antananarivo in Madagascar was conducted from January 2013 to March 2020. HIV-positive patients older than 18 years and receiving antiretroviral therapy as well as those awaiting antiretroviral therapy commencement were included.Among 328 patients enrolled in this study, 167 (51%) presented with at least one type of mucocutaneous lesion. Oral candidiasis was the most common presentation, followed by seborrheic dermatitis and Kaposi sarcoma. Decreases in CD4 cell counts were substantially correlated with oral candidiasis, syphilis, and condyloma acuminatum.According to our findings, oral candidiasis, syphilis, and condyloma acuminatum may serve as clinical indicators for predicting the immune status of patients. As HIV infection progressed and immune function declined, an increase in cutaneous manifestations was observed.©Fandresena Arilala Sendrasoa, Volatiana Mercia Falimiarintsoa, Lala Soavina Ramarozatovo, Fahafahantsoa Rapelanoro Rabenja. Originally published in JMIR Dermatology (http://derma.jmir.org), 15.08.2023.