研究动态
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【偶发垂体腺瘤的临床和进化特征:回顾性多中心研究】

[Clinical and evolutionary characteristics of incidental pituitary adenomas: retrospective multicenter study].

发表日期:2023
作者: Roxana A Damilano, Natalia L Monteserin, Carolina Fux Otta, Jorge H Mukdsi, Paula Mereshian, Marta Andrada,
来源: DIABETES & METABOLISM

摘要:

垂体偶发病灶(PIs)是偶然在垂体成像中发现的,与垂体疾病无关的病变。我们进行了一项横断面、回顾性和描述性的研究,旨在分析科尔多瓦市一组PIs患者的临床和发展特点。共纳入67名患者,其中67%为女性,诊断时的中位年龄为44岁。导致首次成像要求的原因中,慢性或反复头痛最普遍(34%)。肿瘤的中位大小为12毫米,58%为巨大的偶发病灶。男性的病灶显著较大(p = 0.04)。在诊断时,包括两性在内,30%显示超出垂体周围的范围,45%侵犯海绵窦。21%的患者出现了神经-眼科损害。年龄与肿瘤大小呈正相关(r = +0.31,p = 0.001)。91%为非功能性肿瘤,21%的患者在首诊时出现了一个或多个激素缺乏。总体而言,26%需要进行手术。没有接受治疗的大部分患者在随访结束时肿瘤大小没有变化(中位数为42个月)。我们强调了我们系列中巨大偶发病灶的高频率,诊断时视野缺损和垂体功能减退症。虽然大多数未经手术的PIs保持稳定,但存在临床上有意义的病灶的高频率。
Pituitary incidentalomas (PIs) are lesions found incidentally in the pituitary on imaging performed for reasons unrelated to pituitary disease.A cross-sectional, retrospective and descriptive study was carried out with the aim of analyzing the clinical and evolutionary characteristics of a population of patients with PIs in the city of Córdoba.A total of 67 patients were included, 67% female, with a median age at diagnosis of 44 years. Among the reasons that led to requesting the first image, chronic or recurrent headache was the most prevalent (34%). The median tumor size was 12 mm. Fifty-eight percent were macroincidentalomas. Men had significantly larger lesions (p = 0.04). At diagnosis, including both sexes, 30% showed extrasellar extension and 45% invasion of the cavernous sinuses. Neuro-ophthalmological compromise was detected in 21%. A positive correlation was found between age at diagnosis and tumor size (r= +0.31, p = 0.001). Ninety-one percent were non-functioning tumors and at presentation, 21% of patients had one or more hormonal deficiencies. Of the total, 26% required surgery. Most of those who continued without treatment showed no change in tumor size at the end of follow-up (median 42 months).We highlight the high frequency of macroincidentalomas in our series, with visual field defects and hypopituitarism being frequent at diagnosis. Although most non-operated PIs remained stable, there was a high frequency of clinically significant lesions.