鉴于泛癌后转录修饰分析揭示了蛋白质调控的共享模式。
Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation.
发表日期：2023 Aug 09
作者：
Yifat Geffen, Shankara Anand, Yo Akiyama, Tomer M Yaron, Yizhe Song, Jared L Johnson, Akshay Govindan, Özgün Babur, Yize Li, Emily Huntsman, Liang-Bo Wang, Chet Birger, David I Heiman, Qing Zhang, Mendy Miller, Yosef E Maruvka, Nicholas J Haradhvala, Anna Calinawan, Saveliy Belkin, Alexander Kerelsky, Karl R Clauser, Karsten Krug, Shankha Satpathy, Samuel H Payne, D R Mani, Michael A Gillette, Saravana M Dhanasekaran, Mathangi Thiagarajan, Mehdi Mesri, Henry Rodriguez, Ana I Robles, Steven A Carr, Alexander J Lazar, François Aguet, Lewis C Cantley, Li Ding, Gad Getz,
来源：
CELL
摘要：
翻译如下：
翻译：转录后修饰（PTMs）在正常和癌细胞中起着调节细胞信号和生理作用的关键作用。质谱技术的进步使得对PTM水平的高通量、准确和敏感测量成为可能，从而更好地理解它们的作用、普遍性和交互作用。在这里，我们对来自1,110名患者的PTM蛋白质组学数据进行了分析，覆盖了11种癌症类型（其中10种来自美国国家癌症研究所的临床蛋白质组学肿瘤分析联盟[CPTAC]）。我们的研究揭示了涉及重要癌症过程的蛋白乙酰化和磷酸化的全癌症模式。这些模式揭示了来自不同癌症类型的肿瘤亚群，包括那些因磷酸化引起DNA修复失调、因乙酰化引起的代谢调节改变与免疫应答相关、因乙酰化和磷酸化之间的交互作用而受到影响的激酶特异性以及修饰组蛋白调控的改变。总的来说，这个资源突出了PTMs所主导的丰富生物学，并揭示了潜在的新的治疗途径。版权所有© 2023 The Authors. 由Elsevier公司出版。保留所有权利。
Post-translational modifications (PTMs) play key roles in regulating cell signaling and physiology in both normal and cancer cells. Advances in mass spectrometry enable high-throughput, accurate, and sensitive measurement of PTM levels to better understand their role, prevalence, and crosstalk. Here, we analyze the largest collection of proteogenomics data from 1,110 patients with PTM profiles across 11 cancer types (10 from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium [CPTAC]). Our study reveals pan-cancer patterns of changes in protein acetylation and phosphorylation involved in hallmark cancer processes. These patterns revealed subsets of tumors, from different cancer types, including those with dysregulated DNA repair driven by phosphorylation, altered metabolic regulation associated with immune response driven by acetylation, affected kinase specificity by crosstalk between acetylation and phosphorylation, and modified histone regulation. Overall, this resource highlights the rich biology governed by PTMs and exposes potential new therapeutic avenues.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.