新陈代谢和DNA复制是生命中最基本的两个生物功能。新陈代谢的分解支将营养物质分解以产生能量和由新陈代谢的合成支所使用的前体，用于合成大分子。DNA复制消耗能量和前体以忠实地复制基因组，将遗传物质从一代传递到下一代。我们对支撑和调控这两个生物功能的机制有着精确的理解。然而，调控复制到新陈代谢的分子机制及其生物功能大多仍然未知。了解生物如何通过细胞周期动态变化对波动的营养刺激做出回应，并且如何在各种生长条件下以可重复且独特的时序调控DNA合成是很重要的，对整个生命领域都有广泛的影响。在总结奠定代谢控制复制概念的重要研究后，我们回顾了从细菌到人类的与复制相关的代谢数据。然后呈现了支撑这些联系的分子见解，并提出代谢调控复制利用信号系统，调节代谢组稳态以编排复制的时序化。这种控制系统的突出复制表型凸显了其在复制调控以及可能的遗传稳定性和肿瘤发生中的重要性。

Metabolism and DNA replication are the two most fundamental biological functions in life. The catabolic branch of metabolism breaks down nutrients to produce energy and precursors used by the anabolic branch of metabolism to synthesize macromolecules. DNA replication consumes energy and precursors for faithfully copying genomes, propagating the genetic material from generation to generation. We have exquisite understanding of the mechanisms that underpin and regulate these two biological functions. However, the molecular mechanism coordinating replication to metabolism and its biological function remains mostly unknown. Understanding how and why living organisms respond to fluctuating nutritional stimuli through cell-cycle dynamic changes and reproducibly and distinctly temporalize DNA synthesis in a wide-range of growth conditions is important, with wider implications across all domains of life. After summarizing the seminal studies that founded the concept of the metabolic control of replication, we review data linking metabolism to replication from bacteria to humans. Molecular insights underpinning these links are then presented to propose that the metabolic control of replication uses signalling systems gearing metabolome homeostasis to orchestrate replication temporalization. The remarkable replication phenotypes found in mutants of this control highlight its importance in replication regulation and potentially genetic stability and tumorigenesis.