大麻是最常用的娱乐药物，在世界许多地区是非法的。随着越来越多的非刑事化和合法化，大麻在美国和其他国家的使用也在增加。由于在美国大麻被列为1类药物，限制了相关研究，因此大麻的不良影响尚不清楚。尽管数据有限，但大麻通常被认为是一种温和甚至有益的药物。然而，最近的研究表明大麻对心血管和肺部有不良影响，并与恶性肿瘤有关。此外，个案报告显示大麻使用与神经精神障碍有关。随着大麻的日益普及，未成年人的滥用导致过量和毒性事件不断增加。尽管难以检测，大麻中毒可能与驾驶能力受损和车祸有关。总体而言，大麻的使用正在增加，并且在临床数据集中不良影响正在显现。《医学年鉴第75卷》的预期最终在线出版日期为2024年1月。请访问http://www.annualreviews.org/page/journal/pubdates了解修订后的估计日期。

Cannabis, the most commonly used recreational drug, is illicit in many areas of the world. With increasing decriminalization and legalization, cannabis use is increasing in the United States and other countries. The adverse effects of cannabis are unclear because its status as a Schedule 1 drug in the United States restricts research. Despite a paucity of data, cannabis is commonly perceived as a benign or even beneficial drug. However, recent studies show that cannabis has adverse cardiovascular and pulmonary effects and is linked with malignancy. Moreover, case reports have shown an association between cannabis use and neuropsychiatric disorders. With growing availability, cannabis misuse by minors has led to increasing incidences of overdose and toxicity. Though difficult to detect, cannabis intoxication may be linked to impaired driving and motor vehicle accidents. Overall, cannabis use is on the rise, and adverse effects are becoming apparent in clinical data sets. Expected final online publication date for the Annual Review of Medicine, Volume 75 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.