糖酵解重编程是癌症的最重要特征之一，并在癌症进展中起着关键作用。在癌细胞中，葡萄糖代谢的改变满足了自我增殖、血管生成、淋巴管生成、转移等需求，并影响着癌症的免疫逃避、预后评估和治疗效果。RNA的N6-甲基腺苷（m6A）修饰在真核细胞中广泛存在。动态可逆的m6A修饰广泛参与了癌干细胞更新与分化、肿瘤治疗耐药性、肿瘤微环境、肿瘤免疫逃逸和肿瘤代谢的调控。近来，越来越多的证据表明，m6A修饰可以以多种方式影响肿瘤的糖酵解过程，从而调节肿瘤的生物行为。本综述讨论了糖酵解在肿瘤发生和发展中的作用，并详细阐述了m6A修饰通过调控糖酵解对不同肿瘤产生的深远影响。我们认为，经m6A修饰的糖酵解在肿瘤治疗中具有重要意义和潜力。©2023. BioMed Central Ltd., part of Springer Nature.

Glycolytic reprogramming is one of the most important features of cancer and plays an integral role in the progression of cancer. In cancer cells, changes in glucose metabolism meet the needs of self-proliferation, angiogenesis and lymphangiogenesis, metastasis, and also affect the immune escape, prognosis evaluation and therapeutic effect of cancer. The n6-methyladenosine (m6A) modification of RNA is widespread in eukaryotic cells. Dynamic and reversible m6A modifications are widely involved in the regulation of cancer stem cell renewal and differentiation, tumor therapy resistance, tumor microenvironment, tumor immune escape, and tumor metabolism. Lately, more and more evidences show that m6A modification can affect the glycolysis process of tumors in a variety of ways to regulate the biological behavior of tumors. In this review, we discussed the role of glycolysis in tumor genesis and development, and elaborated in detail the profound impact of m6A modification on different tumor by regulating glycolysis. We believe that m6A modified glycolysis has great significance and potential for tumor treatment.© 2023. BioMed Central Ltd., part of Springer Nature.