全股骨置换术是广泛骨肿瘤或术后骨大量丢失的情况下，选择性截肢外的一个选项。长期来看，患者可能需要进行再次手术，这可能会影响功能结果。我们对我中心进行的所有连续股骨全置换手术进行了回顾，以评估长期功能结果和存活情况。回顾了从1997年6月至2022年5月我中心进行的所有股骨全切除和模块化假体置换重建手术的患者。通过WhatsApp使用基于肌肉骨骼肿瘤学会评分系统（MSTS）的谷歌表单对受访者进行了调查，并将其翻译成马来语。数据以肢体和假体的最终存活情况的描述性数据形式呈现。共有10名患者接受了股骨全置换手术。其中8例是骨肉瘤，1例巨细胞瘤，1例软骨黏液纤维瘤。3例骨肉瘤患者因肺转移而死亡；所有患者均在术后早期拥有良好的功能结果，无局部复发。7例患者进行了长期功能评估，随访平均时间为17.6年（范围为10-25年）。股骨全置换手术患者中，有4例具有良好的功能结果（60-80%），无需进行10-25年的再次手术。3例患者出现了髋臼骨侵蚀和慢性疼痛，需要早期进行髋关节置换手术。其中两例并发症包括上面侵蚀和骨丢失，随后采用有钙胶髋臼笼重建进行大范围修复。另一例患者因慢性感染导致全股骨置换术后对远侧股骨假体修复后14年，随后接受限制性半骨盆切除。全股骨置换术提供了良好的长期功能结果和假体存活率，并且是一种有利于肢体保留的手术选择。© 2023马来西亚骨科协会（MOA）。版权所有。

Total femur replacement is an option instead of amputation for extensive bone tumour or after revision surgery with a massive bone loss. Over a long period of time the patients may need revision surgery, and this might affect the functional outcome. We reviewed all consecutive total femur replacements done for primary and revision surgery of primary bone tumours in our centre to evaluate the long-term functional outcome and survival.All patients who had total femur resection and reconstruction with modular endoprosthesis replacement in our centre from June 1997 to May 2022 were reviewed. The respondents were surveyed through WhatsApp using google form which was translated into Bahasa Malaysia based on the Musculoskeletal Tumour Society Scoring System (MSTS). The data were presented as descriptive data on the final survival of the limb and prosthesis.Ten patients underwent total femur replacement. There were eight osteosarcoma, one giant cell tumour and one chondromyxoid fibroma. Three patients with osteosarcoma succumbed to pulmonary metastases; all had good early post-operative functional outcomes without local recurrence. Seven patients were available for long term evaluation of function with a mean follow-up of 17.6 years (ranged 10-25 years). Four patients with total femur replacement had good functional outcomes (60-80%) without revision with 10-25 years follow-up. Three patients experienced acetabulum erosion and chronic pain that required early hip replacements. Two of them were complicated with superior erosions and bone loss and subsequently were managed with massive reconstruction using cemented acetabulum cage reconstruction. The other has diabetes mellitus with chronic infection following revision of distal femur endoprosthesis to total femur replacement and subsequently underwent limited hemipelvectomy after 14 years.Total femur replacement offers a good long term functional outcome and prosthesis survival and is a favourable option for limb salvage surgery.© 2023 Malaysian Orthopaedic Association (MOA). All Rights Reserved.