2012年至2019年期间瑞典全国学校HPV疫苗接种计划的高覆盖率和剂量间隔遵守情况。
High coverage and adherence to dose intervals of the national school-based HPV vaccination program in Sweden during 2012-2019.
发表日期：2023 Oct
作者：
Jiangrong Wang, Eva Herweijer, Sara Nordqvist Kleppe, Susanne Hartwig, Christine Velicer, Carol Koro, Karin Sundström
来源：
Immunity & Ageing
摘要：
对接种覆盖率进行密切监测对于宫颈癌预防工作至关重要。本研究旨在描述瑞典儿童免疫计划适龄接种HPV疫苗的女孩的疫苗接种覆盖率，并对剂次时序遵从性进行估计。从瑞典的疫苗登记中获得了2012年至2019年3月出生于2000-2006年间的女孩的疫苗接种记录。采用相应出生群体的人口中位数数作为分母。通过地区计算了两剂和三剂方案下的全剂疫苗覆盖率和至少接种一剂疫苗的覆盖率。在两剂方案下计算了剂次遵从性。2001-2006年出生的出生群体中，至少接种一剂疫苗的疫苗覆盖率>80%。两剂和三剂方案下的全剂疫苗覆盖率分别为2004-2005年出生的出生群体73.4%和2000-2001年出生的出生群体56.3%。在不同地区的疫苗接种覆盖率之间变化很小。在两剂方案的剂次完成率为91.8%，而在三剂方案的剂次完成率为72.8%。在接受两剂方案的女孩中，93.0%的女孩在第一剂疫苗接种后6-12个月接种了第二剂。总之，我们观察到了高水平的HPV疫苗接种覆盖率，并且地区之间差异很小。两剂方案中的剂次时序遵从性尤其高。为了充分受益于HPV疫苗的影响，进一步推动疫苗接种覆盖率并接种那些不完全参与HPV疫苗接种的女孩至关重要。© 2023 Published by Elsevier Inc.
Close monitoring of vaccination coverage is important for cervical cancer prevention efforts. The study aims to describe the HPV vaccination coverage by dose in girls eligible for HPV vaccination within Sweden's childhood immunization program and provide an estimate on dose timing compliance.Vaccination records between 2012 and March 2019 were obtained for girls born in 2000-2006 from the vaccination registers in Sweden. The mid-time population counts for the respective birth cohorts were taken as the denominator. Full-dose coverage and coverage with at least one dose of the vaccine were calculated within the two-dose and three-dose regimen, by region. Dose compliance was calculated within the two-dose regimen.Vaccination coverage with at least one dose of the vaccine was >80% within birth cohorts 2001-2006. Full-dose coverage within a two-dose and three-dose regimen were 73.4% in birth cohorts 2004-2005, and 56.3% in birth cohorts 2000-2001, respectively. Little variation was observed in vaccination coverage between regions. Dose completion was 91.8%, and 72.8% in girls that initiated a two-dose and three-dose regimen, respectively. Among girls receiving a two-dose regimen, 93.0% received the second dose 6-12 months after dose one.In conclusion, high levels of HPV vaccination coverage were observed with little variation between regions. Dose timing compliance was particularly high in the two-dose regimen. To fully benefit from the impact of HPV vaccination, it will be important to further push the vaccination coverage and reach the girls that do not or partially engage with HPV vaccination.© 2023 Published by Elsevier Inc.