打嗝是指膈肌和肋间肌突然发生的不规则收缩，紧接着是喉部的关闭。其病理生理涉及传入、中枢和传出三个部分。我们对46岁的女性患者进行了双侧膈神经阻滞治疗，该患者患有脑肿瘤并出现持续性打嗝症状，在开始时疗效良好，但后来症状复发。我们在超声引导下进行了双侧膈神经脉冲射频治疗。随访时，打嗝症状消失得到确认，患者24小时后出院。持久或难以治疗的打嗝是一种不常见的疾病，不应轻视。这种方法是一种安全、准确和有效的治疗方法，适用于对保守治疗无效的患者。需要进一步的研究来确定该治疗的安全性和有效性。

Singultus is the sudden onset of erratic diaphragmatic and intercostal muscle contraction immediately followed by laryngeal closure. Pathophysiology involves afferent, central and efferent components. Bilateral phrenic nerve block was performed to a 46-year-old woman with a brain tumor with persistent hiccups, with initially positive response but later symptom recurrence. Bilateral pulsed radiofrequency of the phrenic nerve was performed guided by ultrasonography (US). In the follow-up, absence of hiccups was confirmed. The patient was discharged 24 h later. Persistent or untreatable singultus is an infrequent condition that should not be dismissed. This approach is a safe, accurate and effective therapeutic approach for patient's refractory to conservative treatment. Further studies are needed to establish safety and effectiveness of the treatment.