癌症治疗中的刺激响应型聚合物纳米载体，能够利用肿瘤微环境的微弱变化实现药物的控制释放，在学术界引起了广泛关注。值得注意的是，各种固体肿瘤中都发现了NAD(P)H：醌氧还酶 1(NQO1)的上调表达，由于其在生理条件下能够有效地去酶地还原三甲基锁定(TML)苯醌结构，因此成为有前途的治疗靶点。在本研究中，成功合成了一种新型的氧化还原敏感的碳酸酯单体MTC，并通过开环聚合法制备了其两亲性嵌段共聚物。通过成功自组装成聚乙二醇-b-PMTC胶束，高效地封装了模型药物阿霉素(DOX)。胶束表现出氧化还原敏感的行为，导致药物的快速释放。体外评估证实了其良好的生物相容性和血液相容性。此外，NQO1酶的抑制剂可减少在NQO1过度表达细胞中的药物释放，但对对照细胞没有影响，从而导致存在NQO1酶抑制剂时的细胞毒性降低。总体而言，本研究展示了基于MTC的聚碳酸酯胶束实现在NQO1酶介导的肿瘤微环境中的靶向和特异性药物释放的潜力。因此，基于MTC的聚合物的自组装成纳米胶束在药物传递应用中具有巨大的潜力。

Stimuli-responsive polymer nanocarriers, capable of exploiting subtle changes in the tumor microenvironment for controlled drug release, have gained significant attention in cancer therapy. Notably, NAD(P)H: quinone oxidoreductase 1 (NQO1), found to be upregulated in various solid tumors, represents a promising therapeutic target due to its effective capability to enzymatically reduce trimethyl-locked (TML) benzoquinone structures in a physiological condition. In this study, a novel redox-sensitive carbonate monomer, MTC, was synthesized, and its amphiphilic block copolymers were prepared through ring-opening polymerization. By successfully self-assembling poly(ethylene glycol)-b-PMTC micelles, the model drug doxorubicin (DOX) was encapsulated with high efficiency. The micelles exhibited redox-responsive behavior, leading to rapid drug release. In vitro assessments confirmed their excellent biocompatibility and hemocompatibility. Furthermore, the inhibition of the NQO1 enzyme reduced drug release in NQO1-overexpressed cells but not in control cells, resulting in decreased cytotoxicity in the presence of NQO1 enzyme inhibitors. Overall, this study showcases the potential of MTC-based polycarbonate micelles to achieve targeted and specific drug release in the NQO1 enzyme-mediated tumor microenvironment. Therefore, the self-assembly of MTC-based polymers into nanomicelles holds immense promise as intelligent nanocarriers in drug delivery applications.