津巴布韦帕里雷尼亚特瓦医院就诊的宫颈癌患者的临床和人口特征。
Clinical and demographic characteristics of cervical cancer patients presenting at Parirenyatwa Hospital, Zimbabwe.
发表日期:2021 Dec
作者:
Oppah Kuguyo, Nomsa Tsikai, Senelisiwe Chipo Muradzikwa, Kudakwashe Mhandire, Charles Nhachi, Thulani Magwali, Mugove G Madziyire, Alice Matimba, Collet Dandara
来源:
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要:
宫颈癌是非洲妇女癌症死亡的主要原因,主要是由于晚期诊断。本研究旨在确定津巴布韦宫颈癌患者的危险因素、潜在预后指标和最佳治疗方法。共回顾了1063名宫颈癌患者的医学记录,包括社会人口学、临床、治疗和反应数据。所有数据均使用SPSS 25版进行分析。超过一半的患者处于绝经前期(63%),有2%的人有宫颈癌筛查的病史较低。在肿瘤标本中观察到血吸虫卵的比例为2.4%。超过50%的患者被诊断为3期及以后,并且合并症的频率较高(约68%)。本研究强调了改善津巴布韦宫颈癌筛查教育和接受情况的需求。此外,当前数据为理解非洲人群中宫颈癌病因和治疗反应提供了数据集。
Cervical cancer is the leading cause of cancer deaths in women in Africa, predominately due to late diagnosis. This study aims to identify risk factors, potential prognostic indicators, and optimal treatment modalities for Zimbabwean cervical cancer patients. Medical records for 1063 cervical cancer patients were reviewed for sociodemographic, clinical, treatment, and response data. All data were analysed using SPSS version 25. More than half of the cohort was pre-menopausal (63%) with low (2%) history of cervical cancer screening. Schistosoma ova were observed in 2.4% of the tumour specimens. More than 50% were diagnosed at stage 3 and later, with a high frequency of comorbidities (~68%). This study highlights a need for improving screening education and uptake in Zimbabwe. Moreover, the current data provides a dataset for understanding cervical cancer pathogenesis and treatment responses in an African cohort.