本研究调查了植物油和鱼油在不同n-3 / n-6 PUFAS比率条件下对脂蛋白谱和小鼠4T1乳腺癌发展的影响。雌性Balb/c小鼠（6-7周龄）在七周内摄入含有4.0％脂肪的饮食。在第四周，将动物接种到左后侧腹部的2.5×106 4T1细胞。记录体重和食物摄入量，并测定谷物中的血清脂蛋白谱。分析肿瘤体积，组织病理学和免疫组化研究，髓过氧化物酶和N-乙酰葡萄糖苷酶活性，TNF-α，血红蛋白和VEGF水平。最高的n-3 / n-6比率发现在鱼油中（15.8:1），其次是亚麻仁（2.4:1），菜籽（1：2.1）和大豆（1：9.4）油。体重，食物和热量摄入量，脂蛋白谱，肿瘤重量，肿瘤发展和组织病理学分析没有差异。与大豆油相比，菜籽油增加了细胞增殖量，而鱼油改变了炎症反应，并增加了肿瘤中VEGF的含量。饮食中的脂肪酸类型和高比例的n-3 / n-6 PUFAs对肿瘤中细胞增殖和炎症产生不同影响，强调了饲喂鱼油的动物中嗜中性粒细胞和VEGF水平的上升。

This study investigated the effect of vegetable and fish oils with different n-3 / n-6 PUFAS ratios on the lipoprotein profile and on the development of murine breast cancer 4T1. Female Balb/c mice (6-7 weeks) received diets containing 4.0% fat during seven weeks. On the fourth week, animals were inoculated into the posterior left flank with 2.5 × 106 4T1 cells. Body weight and food intake were registered and the profile serum lipoproteins was determined. Tumor volume, histopathological and immunohistochemical studies, myeloperoxidase and N-acetylglucosaminidase activities, TNF-α, hemoglobin and VEGF levels were analysed. The highest n-3 / n-6 ratio was found in fish oil (15.8:1), followed by linseed (2.4:1), canola (1:2.1) and soybean (1:9.4) oils. Body weight, food and caloric intake, lipoprotein profile, tumor weight, tumor evolution and histopathological analysis were not different. Canola oil increased cell proliferation when compared to soybean oil, and fish oil changed the inflammatory response and increased VEGF in tumors compared to other groups. The type of fatty acid and the high ratio of n-3 / n-6 PUFAs in the diet influenced cell proliferation and inflammation in the tumor differentially, highlighting the increase of neutrophils and VEGF levels in animals fed on fish oil.