癌症治疗引起的心脏损伤对于接受化疗、放疗、免疫疗法和靶向分子疗法的癌症患者来说是一个重要的问题。这些治疗的使用可能导致心脏中的氧化应激和心肌细胞损伤，从而导致心力衰竭和其他心脏并发症。实验证明，某些化疗药物如柚氨醇和环磷酰胺会引起严重的副作用，如心脏纤维化、电生理重塑、慢性氧化应激和炎症等，这可能增加了接受化疗患者心脏疾病发生的风险。与此类似的后果也可能在接受左乳房或肺恶性肿瘤放疗的患者中观察到。多酚类化合物是一类具有抗氧化和抗炎特性的天然化合物，已显示出对抗癌症治疗引起的心脏损伤的潜力。这些化合物已被发现可以减少心脏中的氧化应激、坏死和凋亡，从而保护心脏功能。近年来，携载多酚类化合物的纳米颗粒也为这些化合物的传递提供了新途径，并提高了它们在不同器官中的有效性。这些纳米颗粒可以改善多酚类化合物的生物利用度和功效，同时最小化其毒性。本综述文章总结了多酚类化合物和携载多酚类化合物的纳米颗粒对癌症治疗引起的心脏损伤的保护作用的当前认识。文章讨论了多酚类化合物保护心脏的机制，包括抗氧化和抗炎能力。文章还强调了使用纳米颗粒传递多酚类化合物的潜在益处。版权所有 © 2023 Elsevier Inc.

Cancer therapy-induced heart injury is a significant concern for cancer patients undergoing chemotherapy, radiotherapy, immunotherapy, and also targeted molecular therapy. The use of these treatments can lead to oxidative stress and cardiomyocyte damage in the heart, which can result in heart failure and other cardiac complications. Experimental studies have revealed that chemotherapy drugs such as doxorubicin and cyclophosphamide can cause severe side effects such as cardiac fibrosis, electrophysiological remodeling, chronic oxidative stress and inflammation, etc., which may increase risk of cardiac disorders and attacks for patients that underwent chemotherapy. Similar consequences may also be observed for patients that undergo radiotherapy for left breast or lung malignancies. Polyphenols, a group of natural compounds with antioxidant and anti-inflammatory properties, have shown the potential in protecting against cancer therapy-induced heart injury. These compounds have been found to reduce oxidative stress, necrosis and apoptosis in the heart, thereby preserving cardiac function. In recent years, nanoparticles loaded with polyphenols have also provided for the delivery of these compounds and increasing their efficacy in different organs. These nanoparticles can improve the bioavailability and efficacy of polyphenols while minimizing their toxicity. This review article summarizes the current understanding of the protective effects of polyphenols and nanoparticles loaded with polyphenols against cancer therapy-induced heart injury. The article discusses the mechanisms by which polyphenols protect the heart, including antioxidant and anti-inflammation abilities. The article also highlights the potential benefits of using nanoparticles for the delivery of polyphenols.Copyright © 2023. Published by Elsevier Inc.