聚焦粘附激酶（FAK）是一种非受体酪氨酸激酶，在骨骼系统中具有重要的调控功能。间充质干细胞（MSC）具有显著的迁移和分化能力，是独特骨细胞产生的重要来源和突出的骨发育途径。MSC在组织生物工程和再生医学方面具有广泛的应用，常用于造血支持、免疫调节和缺陷修复，尽管目前的研究还不足。已经发现FAK与骨生物学中许多其他关键信号通路交互，并被认为是信号转导途径中的基本“十字路口”和信号网络中的“节点”，用于介导骨骼系统中MSC谱系发展。在本综述中，我们总结了FAK的结构、特征、细胞信号传导以及与骨骼系统中其他信号通路的相互作用。对FAK及其介导的分子的发现将带来对骨骼发育和骨构建的新认识，以及在骨相关疾病治疗中的潜在治疗用途，如骨质疏松症、骨关节炎和骨肉瘤。版权所有©2023 Elsevier Inc. 发表。

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and distributes important regulatory functions in skeletal system. Mesenchymal stem cell (MSC) possesses significant migration and differentiation capacity, is an important source of distinctive bone cells production and a prominent bone development pathway. MSC has a wide range of applications in tissue bioengineering and regenerative medicine, and is frequently employed for hematopoietic support, immunological regulation, and defect repair, although current research is insufficient. FAK has been identified to cross-link with many other keys signaling pathways in bone biology and is considered as a fundamental "crossroad" on the signal transduction pathway and a "node" in the signal network to mediate MSC lineage development in skeletal system. In this review, we summarized the structure, characteristics, cellular signaling, and the interactions of FAK with other signaling pathways in the skeletal system. The discovery of FAK and its mediated molecules will lead to a new knowledge of bone development and bone construction as well as considerable potential for therapeutic use in the treatment of bone-related disorders such as osteoporosis, osteoarthritis, and osteosarcoma.Copyright © 2023. Published by Elsevier Inc.