为了量化非小细胞肺癌（NSCLC）患者残疾对社会的影响，本研究估计了无残疾寿命（DFLE），DFLE损失，并探讨了它们与生命质量调整的寿命（QALE）和QALE损失之间的关系。我们将国家数据库进行了互连，并应用了滚动算法来估计NSCLC患者的终身生存函数。我们使用EuroQOL-5 Dimensions（EQ-5D）和Barthel指数（BI），对2011年至2020年就诊于我院的NSCLC患者的生活质量和残疾函数进行了重复测量。我们通过模拟诊断年份相同的生命表，选择了年龄和性别匹配的参考者。我们将BI分数≤70的患者归类为需要长期护理，并建立了线性混合模型来估计效用值和残疾分数。我们收集了960例病例和3088次测量。在50-64岁和I-IIIa期、50-64岁和IIIb-IV期、65-89岁和I-IIIa期、65-89岁和IIIb-IV期，没有残疾的测量比例分别为97.3％、89.3％、94.8％和78.3％，对应的DFLE分别为15.3年、2.4年、6.8年和1.2年，损失的DFLE分别为8.1年、20.7年、4.0年和8.6年，表明晚期NSCLC比年龄更具影响力。在晚期的幸存者在几乎所有子项目中都表现出对帮助的增加需求。DFLE似乎与QALE相近，但由于不适和抑郁，QALE要短于DFLE。从社会角度来看，未来的健康技术评估应考虑功能残疾的终身持续时间的影响。早期诊断NSCLC可能会减轻长期护理的负担。© 2023. Springer Nature Limited.

To quantify the societal impact of disability in patients with non-small cell lung cancer (NSCLC), this study estimated the disability-free life expectancy (DFLE), loss-of-DFLE and explored their associations with quality-adjusted life expectancy (QALE) and loss-of-QALE. We interlinked national databases and applied a rolling-over algorithm to estimate the lifetime survival function for patients with NSCLC. Using the EuroQOL-5 Dimension (EQ-5D) and Barthel index (BI), we repeatedly measured the quality-of-life and disability functions of NSCLC patients who visited our hospital from 2011 to 2020. Age-, sex-matched referents were simulated from lifetables of the same calendar year of diagnosis. We categorized BI scores ≤ 70 as in need of long-term care and constructed linear mixed models to estimate the utility values and disability scores. We collected 960 cases and 3088 measurements. The proportions of measurements without disability at age 50-64 and in stage I-IIIa, 50-64 and stage IIIb-IV, 65-89 and stage I-IIIa and 65-89 and stage IIIb-IV were 97.3%, 89.3%, 94.8%,78.3%, corresponding to DFLEs of 15.3, 2.4, 6.8, 1.2 years and losses-of-DFLE of 8.1, 20.7, 4.0, 8.6 years, respectively, indicating that advanced stage had a stronger effect than old age. Survivors in advanced stages showed increased demands for assistance in almost all subitems. The DFLEs seemed to be approximate to the QALEs and the latter were shorter than the former due to discomfort and depression. From a societal perspective, future health technology assessment should consider the impact of lifetime duration of functional disability. Early diagnosis of NSCLC may decrease the burden of long-term care.© 2023. Springer Nature Limited.