细胞因子诱导的凋亡抑制因子1（CIAPIN1）与多种恶性肿瘤的发生和进展严密相关，但其对浸润性乳腺癌（IBC）的影响尚不清楚。本研究旨在研究CIAPIN1在IBC中的潜在诊断和预后意义。利用癌症基因组图谱（TCGA）数据库和肿瘤免疫测定资源（TIMER）数据库，检测IBC中CIAPIN1的表达水平及其与临床病理特征的关系。通过Kaplan-Meier分析、Cox回归分析、受试者工作特征曲线（ROC）和Nomogram模型评估CIAPIN1在IBC中的诊断价值和预后重要性。利用STRING数据库和富集分析发现与CIAPIN1相关的互作蛋白、生物学作用和可能的细胞机制。利用MethSurv数据库和University of Alabama at Birmingham癌症数据分析门户（UALCAN）分析CIAPIN1的甲基化状态。通过Spearman相关分析确定CIAPIN1的表达与TP53、免疫检查点基因和免疫细胞浸润的关系。CIAPIN1的mRNA和蛋白水平在IBC中过度表达，并与T分期、组织学类型、年龄、ER状态、PR状态和PAM50（P<0.001）显著相关。CIAPIN1的过度表达在IBC患者中显著降低整体生存率、远处转移无病生存率（DMFS）和复发无病生存率（P<0.001）。类似地，CIAPIN1的高甲基化与IBC患者的不良预后相关。多变量Cox分析发现CIAPIN1是IBC患者特异性生存（DSS）和无进展生存（PFS）的潜在风险因素。ROC曲线的结果显示CIAPIN1在预测ER（-）、PR（-）和亚洲乳腺癌亚型方面具有更好的准确性。此外，IBC中CIAPIN1的表达水平与免疫细胞浸润、TP53和免疫检查点基因之间存在显著相关性。IBC中CIAPIN1的高表达与各种肿瘤免疫细胞的浸润状态和IBC患者的不良预后显著相关。根据本研究结果，CIAPIN1是一种具有潜在诊断和预后意义的IBC标志物。转化癌症研究版权所有，保留所有权利（2023）。

Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) is strictly associated with the incidence and progress of several malignant tumors, but its effect on invasive breast cancer (IBC) remains unclear. We directed to research the potential diagnostic and prognostic significance of CIAPIN1 in IBC.The Cancer Genome Atlas (TCGA) database and Tumor Immune Estimation Resource (TIMER) database were utilized to examine CIAPIN1 expression level in IBC and its relationship with clinicopathological features. The diagnostic value and prognostic importance of CIAPIN1 in IBC were assessed by Kaplan-Meier analysis, Cox regression analysis, receiver operating characteristic (ROC) curve and nomogram model. The STRING database and enrichment analysis were utilized to discover the interacting proteins, biological roles and possible cellular mechanisms related to CIAPIN1. The methylation status of CIAPIN1 was analyzed using MethSurv database and the University of Alabama at Birmingham Cancer Data Analysis Portal (UALCAN). By using Spearman correlation assessment, how the expression of CIAPIN1 was related to TP53, immune checkpoint genes and immune cell infiltration was determined.CIAPIN1 mRNA and protein levels were overexpressed in IBC, and significantly correlated with T stage, histological type, age, ER status, PR status and PAM50 (P<0.001). CIAPIN1 overexpression significantly decreased overall survival, distant metastasis free survival (DMFS) and relapse free survival in IBC patients (P<0.001). Similarly, hypermethylation of CIAPIN1 was associated with adverse outcomes in IBC patients. Multivariate Cox analysis identified CIAPIN1 as a potential risk factor for disease specific survival (DSS) and progression free survival (PFS) in individuals with IBC. The outcomes of the ROC curve showed that CIAPIN1 had a better accuracy in predicting ER(-), PR(-) and Asian breast cancer subtypes. Furthermore, there was a substantial correlation between the CIAPIN1 expression level in IBC and immune cell infiltration, TP53, and immune checkpoint genes.The high expression of CIAPIN1 in IBC is significantly related to the infiltration status of various tumor immune cells and the poor prognosis of IBC patients. According to this current study, CIAPIN1 is a promising diagnostic and prognostic marker for IBC.2023 Translational Cancer Research. All rights reserved.