肝细胞癌（HCC）是一个显著的全球健康问题，在许多地区具有高患病率。不同地区HCC的病因存在差异，但大多数情况是由长期感染病毒性肝炎引起的。乙型肝炎病毒（HBV）负责超过50%的与病毒相关的HCC，这凸显了HBV在疾病发病机制中的重要性。HBV相关HCC的发展和进展是一个复杂的多步骤过程，涉及宿主、病毒和环境因素。一些研究表明，一些HBV基因组突变以及HBV蛋白质可能破坏与HCC发展相关的细胞信号通路。此外，似乎HBV突变体在致病性、肝病进展、对治疗的反应以及病毒复制方面有所不同。了解HBV基因组变异与宿主信号通路变化的关系将改善我们对HBV相关HCC的分子病因学的理解。此外，研究HBV相关HCC中常见的信号通路失调是发现更具针对性的治疗靶点和开发更有效的HCC治疗策略的必要条件。本综述的目的是探讨HBV在HCC发展中的作用，主要关注HBV基因组变异对HCC相关信号通路的影响。版权所有©2023 Shoraka、Hosseinian、Hasibi、Ghaemi和Mohebbi。

Hepatocellular carcinoma (HCC) is a significant global health issue, with a high prevalence in many regions. There are variations in the etiology of HCC in different regions, but most cases are due to long-term infection with viral hepatitis. Hepatitis B virus (HBV) is responsible for more than 50% of virus-related HCC, which highlights the importance of HBV in pathogenesis of the disease. The development and progression of HBV-related HCC is a complex multistep process that can involve host, viral, and environmental factors. Several studies have suggested that some HBV genome mutations as well as HBV proteins can dysregulate cell signaling pathways involved in the development of HCC. Furthermore, it seems that the pathogenicity, progression of liver diseases, response to treatment and also viral replication are different among HBV mutants. Understanding the relationship between HBV genome variations and host signaling pathway alteration will improve our understanding of the molecular pathogenesis of HBV-related HCC. Furthermore, investigating commonly dysregulated pathways in HBV-related HCC is necessary to discover more specific therapeutic targets and develop more effective strategies for HCC treatment. The objective of this review is to address the role of HBV in the HCC progression and primarily focus on the impacts of HBV genome variations on HCC-related signaling pathways.Copyright © 2023 Shoraka, Hosseinian, Hasibi, Ghaemi and Mohebbi.