上皮性卵巢癌（EOC）的可改变风险因素很少。有证据表明，一些抗高血压药物可能具有预防和/或治疗癌症的作用；因此，我们评估了不同抗高血压药物使用与特定EOC组织类型风险之间的关联。我们的嵌套式病例对照研究涵盖了2004年至2013年间，包括6070名澳大利亚50岁以上被诊断为EOC的女性及30337名匹配的对照组。我们使用多变量条件 logistic 回归估计每种抗高血压药物组（包括 β-肾上腺素受体阻滞剂、血管紧张素转换酶抑制剂、血管紧张素 II 受体拮抗剂、钙通道阻滞剂、利尿剂和 α 受体阻滞剂）的使用史与EOC总体以及浆膜样、子宫内膜样、粘液样、透明细胞型和其他组织类型的风险之间的关联的比值比（OR）和95％置信区间（CI）。我们发现大多数抗高血压药物与EOC风险无关。然而，使用钙通道阻滞剂的女性患上浆膜样EOC的风险降低（OR=0.89，95％CI：0.81，0.98），组合噻嗪类和保钾利尿剂的使用与子宫内膜样EOC的风险增加相关（OR=2.09，95％CI：1.15，3.82）。我们的结果对大多数抗高血压药物没有化学预防作用提供了很少的支持，但我们发现的组织类型特异性关联值得进一步调查。版权所有©2023作者。由Elsevier Ltd.发表。保留所有权利。

Epithelial ovarian cancer (EOC) has few modifiable risk factors. There is evidence that some antihypertensive medicines may have cancer preventive and/or therapeutic actions; therefore, we assessed the associations between use of different antihypertensive medicines and risk of specific EOC histotypes.Our nested case-control study of linked administrative health data included 6070 Australian women aged over 50 years diagnosed with EOC from 2004 to 2013, and 30,337 matched controls. We used multivariable conditional logistic regression to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for the association between ever use of each antihypertensive medicine group, including beta-adrenergic blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, diuretics, and alpha blockers, and the risk of EOC overall and separately for the serous, endometrioid, mucinous, clear cell and other histotypes.We found that most antihypertensive medicines were not associated with risk of EOC. However, women who used calcium channel blockers had a reduced risk of serous EOC (OR= 0.89, 95 % CI:0.81,0.98) and use of combination thiazide and potassium-sparing diuretics was associated with an increased risk of endometroid EOC (OR= 2.09, 95 % CI:1.15,3.82).Our results provide little support for a chemo-preventive role for most antihypertensives, however, the histotype-specific associations we found warrant further investigation.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.