Merkel细胞癌(MCC)是一种罕见、侵袭性的皮肤恶性肿瘤，通常在初诊后的两至三年内高复发。MCC的发病率在过去几十年几乎翻了一番。诊断、评估和治疗MCC的选择有限。MicroRNAs(miRNAs)是一类小的非编码RNA分子，对细胞生物学的许多不同方面起着重要的调控作用。在不同类型的癌症中，许多miRNAs表达异常，其中一些是肿瘤抑制基因，而其他一些则是致癌基因。因此，miRNAs在MCC的诊断、预后和治疗方法上有着巨大的应用潜力。因此，本文章的目标是编制、总结和讨论关于MCC中miRNAs的最新研究，突出其作为诊断和预后生物标志物的潜在临床应用价值。版权所有©2023 Elsevier GmbH。保留所有权利。

Merkel cell carcinoma (MCC) is a rare, aggressive form of skin malignancy with a high recurrence commonly within two to three years of initial diagnosis. The incidence of MCC has nearly doubled in the past few decades. Options for diagnosing, assessing, and treating MCC are limited. MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that play an important role in controlling many different aspects of cell biology. Many miRNAs are aberrantly expressed in distinct types of cancer, with some serving as tumor suppressors and others as oncomiRs. Therefore, the future holds great promise for the utilization of miRNAs in enhancing diagnostic, prognostic, and therapeutic approaches for MCC. Accordingly, the goal of this article is to compile, summarize, and discuss the latest research on miRNAs in MCC, highlighting their potential clinical utility as diagnostic and prognostic biomarkers.Copyright © 2023 Elsevier GmbH. All rights reserved.