左束支传导阻滞（LBBB）被证实与扩张型心肌病（DCM）中的不良预后独立相关。然而，对非特异性室间传导延迟（NSIVCD）的预后数据仍有限且存在冲突。我们旨在评估具有NSIVCD的DCM的预后。共有548名在2016年1月至2017年12月期间接受心血管磁共振成像（CMR）的DCM患者连续入组。该队列被分为四组：LBBB组87例，RBBB组27例，NSIVCD组61例和无室间传导延迟（IVCD）组373例。在中位随访58个月后（四分位数范围：47-65），123名患者达到了组合终点，包括心血管死亡，心脏移植和恶性心律失常。通过Kaplan-Meier分析和Cox比例风险回归分析，分析了不同IVCD模式与DCM结果之间的关系。在548名DCM患者中，共有398名男性（72.6%），平均年龄为46±15岁，范围为18至76岁。在Kaplan-Meier分析中，NSIVCD和LBBB患者的事件率高于无IVCD患者，而RBBB患者则未见上升。多变量Cox回归分析显示，LBBB，NSIVCD，NYHA级别，左室射血分数（LVEF），左室舒张末期内径（LVEDDI），晚期增强负荷量的百分比（LGE％）和全心纵向应变（GLS）与DCM结局独立相关。除LBBB外，NSIVCD是DCM患者的不良预后标志，独立于LVEDDI，NYHA级别，LVEF，LGE％和GLS。© 2023，BioMed Central Ltd.，Springer Nature的一部分。

Left bundle branch block (LBBB) has been confirmed to be independently associated with adverse outcomes in dilated cardiomyopathy (DCM). However, prognostic data on nonspecific intraventricular conduction delay (NSIVCD) are still limited and conflicting. We aimed to evaluate the prognosis of DCM with NSIVCD.A total of 548 DCM patients who underwent cardiovascular magnetic resonance imaging (CMR) from January 2016 to December 2017 were consecutively enrolled. The cohort was divided into four groups: 87 with LBBB, 27 with RBBB, 61 with NSIVCD, and 373 without intraventricular conduction delay (IVCD). After a median follow-up of 58 months (interquartile range: 47-65), 123 patients reached the composite endpoints, which included cardiovascular death, heart transplantation, and malignant arrhythmias. The associations between different patterns of IVCD and the outcomes of DCM were analysed by Kaplan‒Meier analysis and Cox proportional hazards regression analysis.Of 548 DCM patients, there were 398 males (72.6%), and the average age was 46 ± 15 years, ranging from 18 to 76 years. In Kaplan‒Meier analysis, patients with NSIVCD and LBBB showed higher event rates than patients without IVCD, while RBBB patients did not. By multivariate Cox regression analysis, LBBB, NSIVCD, NYHA class, left ventricular ejection fraction (LVEF), indexed left ventricular end-diastolic diameter (LVEDDI), percentage of late gadolinium enhancement mass (LGE%), and global longitudinal strain (GLS) were found to be independently associated with the outcomes of DCM.In addition to LBBB, NSIVCD was an unfavourable prognostic marker in patients with DCM, independent of LVEDDI, NYHA class, LVEF, LGE%, and GLS.© 2023. BioMed Central Ltd., part of Springer Nature.