回顾性队列研究。评估5因子改良版脆弱指数（mFI-5）评分与单节段椎间孔成形术（TLIF）后不良临床和影像学结果的预测能力。我们选取了2012年至2021年之间接受单节段开放或微创TLIF的年龄超过50岁、随访时间至少为1年的所有患者。排除变形、外伤、急诊和肿瘤病例以及进行修复手术的患者。使用包括需用药物治疗的高血压、慢性阻塞性肺疾病、糖尿病、充血性心力衰竭和部分或完全依赖功能状态在内的5个因子计算每位患者的mFI-5评分。进行单变量和多因素的 logistic 回归分析，以评估mFI-5评分对 住院再入院、再手术和术后并发症的影响。我们纳入了156名患者，并根据其脆弱程度进行分组：非脆弱组（mFI=0，n=67）、轻度脆弱组（mFI=1，n=59）和重度脆弱组（mFI≥2，n=30）。多因素分析发现高度脆弱（mFI≥2）是再手术（OR：16.9，CI：2.7-106.9，P=0.003）和相关再入院（OR=16.5，CI：2.6-102.7，P=0.003）的独立预测因子，与非脆弱组相比。mFI-5评分≥2还能预测任何并发症（OR=4.5，CI：1.4-14.3，P=0.01）和邻近节段疾病（ASD）（OR=12.5，CI：1.2-134.0，P=0.037）。高度脆弱与年长成人进行单节段TLIF的相关再入院、再手术、任何并发症和ASD具有预测性。

Retrospective Cohort Study.To determine the predictive capability between the 5-factor modified frailty index (mFI-5) scores and adverse clinical and radiographic outcomes following single-level transforaminal lumbar interbody fusion (TLIF).All patients over the age of 50 undergoing single-level open or minimally invasive TLIF from 2012 to 2021 with a minimum follow-up of 1 year were identified. Deformity, trauma, emergency, and tumor cases were excluded as were patients undergoing revision surgeries. An mFI-5 score was computed for each patient using a set of five factors which included hypertension requiring medication, chronic obstructive pulmonary disease, diabetes mellitus, congestive heart failure, and partially or fully dependent functional status. Univariate and multivariate logistic regression analysis were performed to evaluate the impact of mFI-5 scores on readmissions, reoperations, and postoperative complications.156 patients were included and grouped according to their level of frailty: no-frailty (mFI = 0, n = 67), mild frailty (mFI = 1, n = 59), and severe frailty (mFI = 2+, n = 30). Multivariate analysis found high levels of frailty (mFI = 2+) to be independent predictors of reoperation (OR: 16.9, CI: 2.7 - 106.9, P = .003) and related readmissions (OR = 16.5, CI: 2.6 - 102.7, P = .003) as compared to the no-frailty group. An mFI-5 score of 2+ was also predictive of any complication (OR = 4.5, CI: 1.4 - 14.3, P = .01) and adjacent segment disease (ASD) (OR = 12.5, CI: 1.2 - 134.0, P = .037).High levels of frailty were predictive of related readmissions, reoperations, any complications, and ASD in older adult patients undergoing single-level TLIF.