双酚A（BPA）对人体健康产生有害影响，包括强大的内分泌活性和对癌症发展的潜在影响。过去几十年中，对水和塑料制品中BPA残留物的分析引起了相当大的关注。然而，目前主要使用的常规分析技术无法直接和非破坏性地鉴定塑料制品中正确的BPA种类。因此，本研究展示了硼氮化物量子点（BNQDs）作为一种无机基质在基质辅助激光解吸/电离质谱分析和成像（MALDI-MS和MSI）中对BPA的有效利用。BNQDs表面存在丰富的羟基和氨基团，有利于与BPA形成氢键，增加其电离性和化学选择性。有趣的是，BNQDs基质为具有不同羟基团的酚类有害分子提供了明显的信号。该方法被应用于在环境水中检测纳摩尔级别的BPA，并且还允许对塑料和奶嘴中的BPA进行非破坏性和原位映射。本研究提供了一种新的策略，利用MALDI-MS和MSI在环境相关样品中利用纳米材料作为无机基质分析小分子污染物。版权所有 © 2023 Elsevier B.V. 发表。

Bisphenol A (BPA) displays harmful effects on the human health, including potent endocrine activity and potential impact on the development of cancer. Analysis BPA residues in water and plastic products attracted considerable attention in the past decades. However, dominantly used conventional analysis techniques are unable to directly and non-destructively identify the correct species of BPA in plastic products. Hence, this study demonstrates the effective utilisation of boron nitride quantum dots (BNQDs) as an inorganic matrix in matrix-assisted laser desorption/ionization mass spectrometry analysis and imaging (MALDI-MS & MSI) for BPA. The presence of abundant hydroxyl and amino groups on the BNQDs' surface is favourable for the formation of hydrogen bonds with BPA, and increases their ionization and chemoselectivity. Intriguingly, the BNQDs matrix offers a distinct signal for phenolic hazardous molecules featuring different hydroxyl groups. The method was applied to detect BPA at nanomolar level in environmental water, and also allowed non-destructive and in situ mapping of BPA in plastics and pacifiers. This research provides a novel strategy for adapting nanomaterials as inorganic matrices for analysis of small molecular pollutants in environmentally relevant samples using MALDI-MS & MSI.Copyright © 2023. Published by Elsevier B.V.