在转录水平上，选择性剪接控制基因表达，产生结构和功能上不同的蛋白质异二聚体。异常的选择性剪接极大地影响细胞发育，并在许多种类的癌症侵袭和转移中发挥重要作用。最近的研究表明，选择性剪接能够改变肿瘤微环境，并在肿瘤微环境中调控重构、免疫和炎症等过程。然而，关于选择性剪接与肿瘤微环境之间复杂关系的综合文献综述尚未出现。因此，本综述旨在搜集关于该主题的所有最新数据，并提供关于癌症治疗和潜在预后标志的新视角。版权所有 © 2023 作者。由 Elsevier B.V. 出版。保留所有权利。

Alternative splicing controls gene expression at the transcriptional level, producing structurally and functionally distinct protein heterodimers. Aberrant alternative splicing greatly affects cell development and plays an important role in the invasion and metastasis of many types of cancer. Recently, it has been shown that alternative splicing can alter the tumor microenvironment and regulate processes such as remodeling, immunity, and inflammation in the tumor microenvironment. However, there is no comprehensive literature review of the complex relationship between alternative splicing and the tumor microenvironment. Therefore, this review aims to collect all the latest data on this topic and provide a new perspective on the therapeutic and potential prognostic markers of cancer.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.