细胞功能依赖于代谢反应的时空动态。在组织的所有生理病理过程中，机械力会影响膜、酶、细胞器和代谢基因程序的调节因子的结构和功能，从而调节细胞代谢。反过来，代谢途径的反馈作用影响了细胞和组织的物理性质。因此，代谢和组织力学是动态交织并不断相互作用的。癌症类似于生态系统，包括嵌入改变的细胞外基质中的肿瘤细胞和各种亚群的基质细胞。癌症的进展，从起始到晚期和转移，由基因突变驱动，并受肿瘤微环境中的物理和代谢改变的重要影响。这些改变也在癌细胞逃避免疫监视和抗药性发展方面起着关键作用。在这里，我们重点强调新出现的证据显示肿瘤和基质细胞中的机械代谢电路调节了肿瘤进展的多个关键过程，并讨论了通过干预这些电路来改善治疗方法的潜在途径。© 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all physiopathological processes of tissues, mechanical forces impact the structure and function of membranes, enzymes, organelles and regulators of metabolic gene programs, thus regulating cell metabolism. In turn, metabolic pathways feedback impacts the physical properties of cell and tissues. Hence, metabolism and tissue mechanics are dynamically intertwined and continuously interact. Cancer is akin to an ecosystem, comprising tumor cells and various subpopulations of stromal cells embedded in an altered extracellular matrix. The progression of cancer, from initiation to advanced stage and metastasis, is driven by genetic mutations and crucially influenced by physical and metabolic alterations in the tumor microenvironment. These alterations also play a pivotal role in cancer cells evasion from immune surveillance and in developing resistance to treatments. Here, we highlight emerging evidence showing that mechano-metabolic circuits in cancer and stromal cells regulate multiple processes crucial for tumor progression and discuss potential approaches to improve therapeutic treatments by interfering with these circuits.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.