乳腺癌已超过肺癌成为全球第一位癌症，侵袭和转移仍然是乳腺癌患者死亡的主要原因。肿瘤微环境（tumor microenvironment，TME）是由血管网络滋养的肿瘤细胞生长的重要场所，TME的各种组分与癌细胞强烈相互作用，并是肿瘤进展和转移的重要机制之一。近年来，许多研究报告指出，长链非编码RNA（long non-coding RNAs，LncRNAs）参与了TME的形成并影响了肿瘤发生和转移的过程。本文综述了LncRNA在乳腺癌TME中的基本特性和功能角色，并介绍了LncRNA在乳腺癌微环境中通过三个方向（免疫细胞、非免疫细胞和TME中的细胞外基质）诱导乳腺癌发展和转移的各种机制，为临床实践提供了潜在的生物标志物或治疗靶点。版权所有 © 2023 Elsevier B.V. 保留所有权利。

Breast cancer has surpassed lung cancer as the number one cancer worldwide, and invasion and metastasis are still the main causes of death in breast cancer patients. The tumor microenvironment (TME) is an important site for the growth of tumor cells nourished by vascular networks, and various components of the TME interact strongly with cancer cells and are one of the important mechanisms of tumor progression and metastasis. In recent years, many studies have reported that long non-coding RNAs (LncRNAs) are involved in the formation of TME and influence the process of tumorigenesis and metastasis. This paper reviews the basic characteristics and functional roles of LncRNA in breast cancer TME and introduces the various mechanisms of LncRNA in breast cancer microenvironment that induce breast cancer development and metastasis in three directions: immune cells, non-immune cells, and extracellular matrix in TME, providing potential biomarkers or therapeutic targets for clinical practice.Copyright © 2023 Elsevier B.V. All rights reserved.