胰腺癌是全球的主要死亡原因。虽然已经发现了与其相关的关键基因变化，但是疾病的进展在分子水平上的致病机制尚不清楚。特别是胰腺腺癌（PDAC）的组织微环境通常具有高度的基质含量，免疫细胞招募稀缺以及神经纤维的存在。信息素及其受体（plexin和neuropilin）构成了广泛的调控信号家族，这些信号调控神经元、内皮细胞、免疫细胞、胚胎发育、正常组织稳态以及人类肿瘤的微环境。我们关注这些分子信号在胰腺癌的进展中的作用，通过实验研究和临床研究揭示，包括癌症治疗的新方法。 版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Pancreatic cancer is a major cause of demise worldwide. Although key associated genetic changes have been discovered, disease progression is sustained by pathogenic mechanisms that are poorly understood at the molecular level. In particular, the tissue microenvironment of pancreatic adenocarcinoma (PDAC) is usually characterized by high stromal content, scarce recruitment of immune cells, and the presence of neuronal fibers. Semaphorins and their receptors, plexins and neuropilins, comprise a wide family of regulatory signals that control neurons, endothelial and immune cells, embryo development, and normal tissue homeostasis, as well as the microenvironment of human tumors. We focus on the role of these molecular signals in pancreatic cancer progression, as revealed by experimental research and clinical studies, including novel approaches for cancer treatment.Copyright © 2023 Elsevier Ltd. All rights reserved.