肿瘤微环境（TME）中起重要作用的髓系抑制性免疫细胞（MDSCs）通过诱导免疫抑制，推动肿瘤免疫逃逸。MDSCs的扩张和功能与来自肿瘤细胞、基质细胞和激活的免疫细胞在TME中诱导的信号通路密切相关。虽然这些通路已得到很好的表征，但对涉及其中的表观遗传调控因子的理解还不完整。由于组蛋白修饰是MDSCs中最常研究的表观遗传变化，本文总结了关于组蛋白修饰在MDSCs中作用的当前研究进展。首先，我们讨论了TME对MDSCs中组蛋白修饰的影响，重点放在指导MDSC分化和功能的组蛋白修饰和修饰酶。此外，我们还强调利用调节组蛋白修饰来逆转MDSC诱导的免疫抑制的当前表观遗传干预，并讨论了未来研究方向，以更充分地了解组蛋白修饰在MDSCs中的作用。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Myeloid-derived suppressor cells (MDSCs) are important components of the tumor microenvironment (TME), which drive the tumor immune escape by inducing immunosuppression. The expansion and function of MDSCs are tightly associated with signaling pathways induced by molecules from tumor cells, stromal cells, and activated immune cells in the TME. Although these pathways have been well-characterized, the understanding of the epigenetic regulators involved is incomplete. Since histone modifications are the most studied epigenetic changes in MDSCs, we summarize current knowledge on the role of histone modifications in MDSCs within this review. We first discuss the influence of the TME on histone modifications in MDSCs, with an emphasis on histone modifications and modifiers that direct MDSC differentiation and function. Furthermore, we highlight current epigenetic interventions that can reverse MDSC-induced immunosuppression by modulating histone modifications and discuss future research directions to fully appreciate the role of histone modifications in MDSCs.Copyright © 2023 Elsevier Ltd. All rights reserved.