由于其独特的结构、物理化学性质和生物相容性，硫化铁纳米材料已成功地应用于细菌感染治疗和催化-铁死细胞联合肿瘤治疗作为治疗剂。然而，对铁硫化物的生物医学研究和对其生物学功能的理解不足，以及铁硫化物纳米材料如何影响疾病中的活性氧类物质（ROS）仍然未知。急性肾损伤（AKI）与高水平的ROS相关，因此纳米医学介导的抗氧化治疗已成为其缓解的新策略。在这里，用谷胱甘肽（GSH）和铁离子（Fe3+）（简称为GFeSNs）通过水热法合成了麦金纳石纳米酶模拟剂，然后评价其作为与ROS相关的AKI治疗的ROS清除剂。GFeSNs通过多种类酶的协同作用和氢多硫化物释放性能表现出广谱的ROS清除能力。此外，体外和体内实验均证明，GFeSNs在极低剂量下展示出优异的对抗ROS诱导损伤的细胞保护效果，并显著改善了AKI的治疗效果。鉴于其协同的抗氧化性能和高生物相容性，GFeSNs在AKI和其他ROS相关疾病的治疗中具有巨大潜力。© 2023. BioMed Central Ltd., Springer Nature的一部分。

Iron sulfide nanomaterials have been successfully employed as therapeutic agents for bacterial infection therapy and catalytic-ferroptosis synergistic tumor therapy due to their unique structures, physiochemical properties, and biocompatibility. However, biomedical research and understanding of the biological functions of iron sulfides are insufficient, and how iron sulfide nanomaterials affect reactive oxygen species (ROS) in diseases remains unknown. Acute kidney injury (AKI) is associated with high levels of ROS, and therefore nanomedicine-mediated antioxidant therapy has emerged as a novel strategy for its alleviation.Here, mackinawite nanozymes were synthesized from glutathione (GSH) and iron ions (Fe3+) (denoted as GFeSNs) using a hydrothermal method, and then evaluated as ROS scavengers for ROS-related AKI treatment. GFeSNs showed broad-spectrum ROS scavenging ability through synergistic interactions of multiple enzymes-like and hydrogen polysulfide-releasing properties. Furthermore, both in vitro and in vivo experiments demonstrated that GFeSNs exhibited outstanding cytoprotective effects against ROS-induced damage at extremely low doses and significantly improved treatment outcomes in AKI.Given the synergetic antioxidant properties and high biocompatibility, GFeSNs exhibit great potential for the treatment of AKI and other ROS-associated diseases.© 2023. BioMed Central Ltd., part of Springer Nature.