高级别胶质瘤是中枢神经系统中最致命的原发肿瘤之一。尽管目前有许多新型免疫治疗方法正在研发中，但在临床研究中很难取得突破性的结果。这可能是由于胶质瘤的抑制性肿瘤微环境限制了目前免疫治疗的主要靶点——特定免疫细胞（例如T细胞）的功能。然而，富集于肿瘤中的肿瘤相关巨噬细胞在胶质瘤的发展中起着重要作用，已成为免疫治疗的研究热点。本文重点介绍了肿瘤相关巨噬细胞作为胶质瘤治疗靶点或治疗工具的当前研究进展，并提供了一些潜在的研究方向。© 2023. Nature Publishing Group UK.

High-grade glioma is one of the deadliest primary tumors of the central nervous system. Despite the many novel immunotherapies currently in development, it has been difficult to achieve breakthrough results in clinical studies. The reason may be due to the suppressive tumor microenvironment of gliomas that limits the function of specific immune cells (e.g., T cells) which are currently the primary targets of immunotherapy. However, tumor-associated macrophage, which are enriched in tumors, plays an important role in the development of GBM and is becoming a research hotspot for immunotherapy. This review focuses on current research advances in the use of macrophages as therapeutic targets or therapeutic tools for gliomas, and provides some potential research directions.© 2023. Nature Publishing Group UK.