白人美国人、阿拉巴马非洲裔美国人和俄克拉荷马美洲印第安人结直肠癌的分子差异。
Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians.
发表日期：2023 Aug 19
作者：
Hiroshi Y Yamada, Chao Xu, Kenneth L Jones, Philip H O'Neill, Madka Venkateshwar, Srikanth Chiliveru, Hyung-Gyoon Kim, Mark Doescher, Katherine T Morris, Upender Manne, Chinthalapally V Rao
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
在美国，大多数癌症样本的分析对象都是白人，导致种族和民族治疗结果产生偏差。阿拉巴马州的非裔美国人（AA）和奥克拉荷马州的美洲印第安人（AI）的结直肠癌（CRC）发病率和死亡率较高。我们假设种族之间的差异可能部分解释了这些差异。因此，我们比较了阿拉巴马州AA、奥克拉荷马州AI和两州的白人之间CRC转录组的特征。与白人的CRC相比，AA的CRC表现出（a）细胞因子和液泡运输的增加、抗肿瘤免疫活性调节以及（b）ID1/BMP/SMAD通路、IL22RA1、APOBEC3和黏蛋白的表达降低；AI则表现出（c）PTGS2 / COX2（NSAID靶标/前癌症性炎症）和剪接调节因子的高表达以及（d）肿瘤抑制活性的降低（例如，TOB2、PCGF2、BAP1）。因此，针对白人CRC患者设计的靶向策略可能对AA/AI效果较差。这些发现阐明了发展优化干预措施以克服种族CRC差异的需求。© 2023. Nature Publishing Group UK.
In the US, the majority of cancer samples analyzed are from white people, leading to biases in racial and ethnic treatment outcomes. Colorectal cancer (CRC) incidence and mortality rates are high in Alabama African Americans (AAs) and Oklahoma American Indians (AIs). We hypothesized that differences between racial groups may partially explain these disparities. Thus, we compared transcriptomic profiles of CRCs of Alabama AAs, Oklahoma AIs, and white people from both states. Compared to CRCs of white people, CRCs of AAs showed (a) higher expression of cytokines and vesicle trafficking toward modulated antitumor-immune activity, and (b) lower expression of the ID1/BMP/SMAD axis, IL22RA1, APOBEC3, and Mucins; and AIs had (c) higher expression of PTGS2/COX2 (an NSAID target/pro-oncogenic inflammation) and splicing regulators, and (d) lower tumor suppressor activities (e.g., TOB2, PCGF2, BAP1). Therefore, targeting strategies designed for white CRC patients may be less effective for AAs/AIs. These findings illustrate needs to develop optimized interventions to overcome racial CRC disparities.© 2023. Nature Publishing Group UK.